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Plexiform Neurofibroma Summary

Description: A type of neurofibroma manifesting as a diffuse overgrowth of subcutaneous tissue, usually involving the face, scalp, neck, and chest but occasionally occurring in the abdomen or pelvis. The tumors tend to progress, and may extend along nerve roots to eventually involve the spinal roots and spinal cord. This process is almost always a manifestation of NEUROFIBROMATOSIS 1. (From Adams et al., Principles of Neurology, 6th ed, p1016; J Pediatr 1997 Nov;131(5):678-82)

Also Known As: Neurofibroma, Plexiform; Tumor Royale; Elephantiasis Neuromatoses; Neurofibromas, Plexiform; Neuroma, Plexiform Show All >>

Networked: 134 relevant articles (3 outcomes, 24 trials/studies) for this Disease

Key Drugs and Agents for Plexiform Neurofibroma

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Interferons : 1 outcome in 1 result : IBA
  2. imatinib (Gleevec) : 2 studies in 5 results : FDA 3
  3. Sirolimus (Rapamycin) : 2 studies in 3 results : FDA 2
  4. Antibodies : 2 studies in 3 results : IBA
  5. Farnesyltranstransferase (Farnesyltransferase) : 2 studies in 2 results : IBA
  6. tipifarnib (R115777) : 2 studies in 2 results : IBA
  7. pirfenidone : 2 studies in 2 results : IBA
  8. Neurofibromin 1 (Neurofibromin) : 1 study in 5 results : IBA
  9. Fluorodeoxyglucose F18 (Fludeoxyglucose F 18) : 1 study in 3 results : FDA 2
  10. Stem Cell Factor : 1 study in 3 results : IBA
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Diseases Related to Plexiform Neurofibroma

  1. Neoplasms (Cancer)
  2. Pain (Aches)
  3. Neurofibromatosis 1 (Neurofibromatosis Type I)
  4. Neurofibroma
  5. Nerve Sheath Neoplasms (Nerve Sheath Neoplasm)
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Key Therapies for Plexiform Neurofibroma

Efficacy Chart >>
  1. Gas Lasers : 1 outcome in 4 results
  2. Transplants (Transplant) : 1 outcome in 3 results
  3. Aftercare (After-Treatment) : 1 outcome in 2 results
  4. Heterologous Transplantation (Xenotransplantation) : 1 study in 3 results
  5. Facial Transplantation : 2 results
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