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Primitive Neuroectodermal Tumors (PNET) Summary

Description: A group of malignant tumors of the nervous system that feature primitive cells with elements of neuronal and/or glial differentiation. Use of this term is limited by some authors to central nervous system tumors and others include neoplasms of similar origin which arise extracranially (i.e., NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL). This term is also occasionally used as a synonym for MEDULLOBLASTOMA. In general, these tumors arise in the first decade of life and tend to be highly malignant. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2059)

Also Known As: PNET; Primitive Neuroectodermal Tumor; Ependymoblastoma; Tumor, Primitive Neuroectodermal; Spongioblastoma Show All >>

Networked: 1219 relevant articles (61 outcomes, 179 trials/studies) for this Disease

Key Drugs and Agents for Primitive Neuroectodermal Tumors

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. everolimus : 13 outcomes 24 studies in 45 results : FDA 2
  2. sunitinib (Sutent) : 9 outcomes 17 studies in 41 results : FDA 2
  3. Etoposide (VP 16) : 5 outcomes 1 study in 30 results : FDA 16 Generic
  4. Carboplatin (JM8) : 4 outcomes 1 study in 19 results : FDA 29 Generic
  5. Cyclophosphamide (Cytoxan) : 3 outcomes 4 studies in 20 results : FDA 10 Generic
  6. Vincristine (Oncovin) : 3 outcomes 2 studies in 18 results : FDA 17 Generic
  7. Octreotide (Sandostatin) : 2 outcomes 4 studies in 12 results : FDA 14 Generic
  8. Doxorubicin (Adriamycin) : 2 outcomes 1 study in 17 results : FDA 12 Generic
  9. Ifosfamide : 2 outcomes 1 study in 16 results : FDA 7 Generic
  10. Somatostatin (Somatotropin Release-Inhibiting Factor) : 2 outcomes 1 study in 11 results : IBA
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Diseases Related to Primitive Neuroectodermal Tumors

  1. Medulloblastoma
  2. Primitive Neuroectodermal Tumors (PNET)
  3. Neoplasms (Cancer)
  4. Neuroendocrine Tumors (Neuroendocrine Tumor)
  5. Ewing's Sarcoma (Sarcoma, Ewing)
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Key Therapies for Primitive Neuroectodermal Tumors

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 13 outcomes 28 studies in 204 results
  2. Radiotherapy : 6 outcomes 16 studies in 98 results
  3. Adjuvant Chemotherapy : 2 outcomes 4 studies in 21 results
  4. Combination Drug Therapy (Combination Chemotherapy) : 2 outcomes 1 study in 8 results
  5. Heterologous Transplantation (Xenotransplantation) : 1 outcome 5 studies in 16 results
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