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Endodermal Sinus Tumor (Endodermal Sinus Tumors) Summary

Description: An unusual and aggressive tumor of germ-cell origin that reproduces the extraembryonic structures of the early embryo. It is the most common malignant germ cell tumor found in children. It is characterized by a labyrinthine glandular pattern of flat epithelial cells and rounded papillary processes with a central capillary (Schiller-Duval body). The tumor is rarely bilateral. Before the use of combination chemotherapy, the tumor was almost invariably fatal. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1189)

Also Known As: Endodermal Sinus Tumors; Yolk Sac Tumor; Tumor, Endodermal Sinus; Tumor, Yolk Sac; Tumors, Endodermal Sinus Show All >>

Networked: 590 relevant articles (31 outcomes, 24 trials/studies) for this Disease

Key Drugs and Agents for Endodermal Sinus Tumor

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Cisplatin (Platino) : 7 outcomes 3 studies in 51 results : FDA 6 Generic
  2. alpha-Fetoproteins (AFP) : 4 outcomes 10 studies in 242 results : IBA
  3. Bleomycin (Blenoxane) : 3 outcomes 2 studies in 38 results : FDA 7 Generic
  4. Etoposide (VP 16) : 2 outcomes 2 studies in 24 results : FDA 16 Generic
  5. Vinblastine (Vinblastine Sulfate) : 2 outcomes in 24 results : FDA 7
  6. Glypicans : 1 outcome 1 study in 11 results : IBA
  7. VAC protocol : 1 outcome 1 study in 1 result : IBA
  8. Cyclophosphamide (Cytoxan) : 1 outcome in 12 results : FDA 10 Generic
  9. Platinum : 1 outcome in 10 results : IBA
  10. Alkaline Phosphatase : 1 outcome in 3 results : IBA
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Diseases Related to Endodermal Sinus Tumor

  1. Neoplasms (Cancer)
  2. Embryonal Carcinoma
  3. Choriocarcinoma
  4. Germinoma
  5. Teratoma (Teratoid Tumor)
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Key Therapies for Endodermal Sinus Tumor

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 13 outcomes 1 study in 134 results
  2. Combination Drug Therapy (Combination Chemotherapy) : 4 outcomes 1 study in 31 results
  3. Radiotherapy : 2 outcomes in 12 results
  4. Lymph Node Excision (Lymph Node Dissection) : 2 outcomes in 10 results
  5. Adjuvant Chemotherapy : 1 outcome 1 study in 10 results
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