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Cytoplasmic and Nuclear Receptors (Nuclear Receptors) Summary

Description: Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.

Also Known As: Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Cytoplasmic Hormone Receptors; Cytoplasmic Receptors; Cytosol and Nuclear Receptors Show All >>

Networked: 916 relevant articles (16 outcomes, 93 trials/studies) for this Bio-Agent

Key Diseases for which Cytoplasmic and Nuclear Receptors is Relevant

  1. Neoplasms (Cancer) : 6 outcomes 14 studies in 207 results
  2. Liver Diseases (Liver Disease) : 2 outcomes 5 studies in 27 results
  3. Infection : 2 outcomes 1 study in 24 results
  4. Prostatic Neoplasms (Prostate Cancer) : 1 outcome 4 studies in 21 results
  5. Cholestasis : 1 outcome 2 studies in 30 results
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Drugs Related to Cytoplasmic and Nuclear Receptors

  1. Retinoids
  2. Transcription Factors (Transcription Factor)
  3. Ligands
  4. Hormones
  5. Vitamin D
  6. Retinoid X Receptors (Retinoid X Receptor)
  7. Steroids
  8. Steroid Receptors (Steroid Receptor)
  9. Monoclonal Antibodies
  10. PPAR gamma
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Therapies Related to Cytoplasmic and Nuclear Receptors

  1. Chemoprevention
  2. Ligation
  3. Therapeutics
  4. Drug Therapy (Chemotherapy)
  5. Transplants (Transplant)
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