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Myocardial Stunning (Stunned Myocardium) Summary

Description: Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity. It occurs frequently, both in the experimental laboratory and in clinical medicine. Since stunned myocardium occurs adjacent to necrotic tissue after prolonged coronary occlusion, many myocardial infarcts may be a mixture of necrotic and stunned tissue. (Braunwald, Heart Disease, 1992, p1176)

Also Known As: Stunned Myocardium; Myocardium, Stunned; Stunning, Myocardial; Hibernation, Myocardial; Myocardial Hibernation

Networked: 916 relevant articles (78 outcomes, 131 trials/studies) for this Disease

Key Drugs and Agents for Myocardial Stunning

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Dobutamine : 6 outcomes 6 studies in 48 results : FDA 15 Generic
  2. simendan (Levosimendan) : 6 outcomes 4 studies in 19 results : IBA
  3. Adenosine Triphosphate (ATP) : 5 outcomes 9 studies in 50 results : IBA
  4. Adenosine : 4 outcomes 9 studies in 52 results : FDA 19 Generic
  5. Calcium : 3 outcomes 10 studies in 89 results : IBA
  6. Catalase : 3 outcomes 3 studies in 9 results : IBA
  7. Oxygen : 2 outcomes 11 studies in 63 results : IBA
  8. Free Radicals : 2 outcomes 4 studies in 39 results : IBA
  9. Free Radical Scavengers : 2 outcomes 4 studies in 8 results : IBA
  10. Isoflurane : 2 outcomes 2 studies in 14 results : FDA 7 Generic
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Diseases Related to Myocardial Stunning

  1. Ischemia
  2. Reperfusion Injury
  3. Myocardial Infarction
  4. Infarction
  5. Myocardial Ischemia (Ischemic Heart Diseases)
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Key Therapies for Myocardial Stunning

Efficacy Chart >>
  1. Angioplasty (Angioplasty, Transluminal) : 3 outcomes 2 studies in 18 results
  2. Off-Pump Coronary Artery Bypass (Coronary Artery Bypass, Off Pump) : 1 outcome in 3 results
  3. General Anesthesia : 1 outcome in 1 result
  4. Induced Heart Arrest (Cardioplegia) : 1 study in 10 results
  5. Coronary Balloon Angioplasty (Percutaneous Transluminal Coronary Angioplasty) : 1 study in 4 results
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