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Polymyositis Summary

Description: Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders. The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. The illness may occur at any age, but is most frequent in the fourth to sixth decade of life. Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (Adams et al., Principles of Neurology, 6th ed, pp1404-9)

Also Known As: Polymyositis Ossificans; Polymyositis, Idiopathic; Idiopathic Polymyositides; Idiopathic Polymyositis; Multiple Myositis Show All >>

Networked: 1539 relevant articles (91 outcomes, 109 trials/studies) for this Disease

Key Drugs and Agents for Polymyositis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Cyclosporine (Ciclosporin) : 12 outcomes in 37 results : FDA 20 Generic
  2. Immunoglobulins (Immunoglobulin) : 11 outcomes 7 studies in 47 results : IBA
  3. Adrenal Cortex Hormones (Corticosteroids) : 10 outcomes 3 studies in 62 results : IBA
  4. Tacrolimus (Prograf) : 9 outcomes 2 studies in 19 results : FDA 7 Generic
  5. Intravenous Immunoglobulins (IVIG) : 8 outcomes 8 studies in 47 results : FDA 1
  6. Prednisolone (Predate) : 6 outcomes 1 study in 37 results : FDA 55 Generic
  7. Azathioprine (Imuran) : 5 outcomes 2 studies in 28 results : FDA 7 Generic
  8. Steroids : 5 outcomes in 21 results : IBA
  9. Methotrexate (Mexate) : 4 outcomes 2 studies in 32 results : FDA 8 Generic
  10. I-antigen : 4 outcomes in 12 results : IBA
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Diseases Related to Polymyositis

  1. Dermatomyositis (Dermatopolymyositis)
  2. Interstitial Lung Diseases (Interstitial Lung Disease)
  3. Muscular Diseases (Myopathy)
  4. Myasthenia Gravis
  5. Myositis (Idiopathic Inflammatory Myopathies)
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Key Therapies for Polymyositis

Efficacy Chart >>
  1. Resistance Training : 3 outcomes 2 studies in 7 results
  2. Aftercare (After-Treatment) : 2 outcomes 2 studies in 8 results
  3. Plasma Exchange : 2 outcomes 1 study in 13 results
  4. Drug Therapy (Chemotherapy) : 2 outcomes 1 study in 11 results
  5. Immunotherapy : 1 outcome in 6 results
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