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Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia) Summary

Description: A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)

Also Known As: Progressive External Ophthalmoplegia; CPEO; Ocular Muscular Dystrophy; Ophthalmoplegia, Chronic Progressive External; Graefe's Disease Show All >>

Networked: 446 relevant articles (5 outcomes, 43 trials/studies) for this Disease

Key Drugs and Agents for Chronic Progressive External Ophthalmoplegia

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Mitochondrial DNA (mtDNA) : 1 outcome 24 studies in 282 results : IBA
  2. coenzyme Q10 (CoQ10) : 1 outcome 1 study in 3 results : IBA
  3. Carnitine (L-Carnitine) : 1 outcome 1 study in 2 results : FDA 9 Generic
  4. Ubiquinone : 1 outcome 1 study in 1 result : IBA
  5. Neuropathy ataxia and retinis pigmentosa : 1 outcome in 1 result : IBA
  6. Electron Transport Complex IV (Cytochrome c Oxidase) : 5 studies in 29 results : IBA
  7. DNA (Deoxyribonucleic Acid) : 2 studies in 28 results : IBA
  8. Ile Transfer RNA : 2 studies in 9 results : IBA
  9. Tyr Transfer RNA : 2 studies in 4 results : IBA
  10. Phosphorus : 2 studies in 3 results : IBA
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Diseases Related to Chronic Progressive External Ophthalmoplegia

  1. Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia)
  2. Kearns-Sayre Syndrome
  3. Mitochondrial Myopathies (Mitochondrial Myopathy)
  4. Retinitis Pigmentosa (Pigmentary Retinopathy)
  5. Ataxia (Dyssynergia)
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Key Therapies for Chronic Progressive External Ophthalmoplegia

Efficacy Chart >>
  1. Mechanical Ventilators (Ventilator) : 1 study in 2 results
  2. Ligation : 1 study in 2 results
  3. Lasers (Laser) : 1 study in 2 results
  4. Transplants (Transplant) : 1 result
  5. Heart Transplantation (Grafting, Heart) : 1 result
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