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MERRF Syndrome (Myoclonic Epilepsy and Ragged Red Fibers) Summary

Description: A mitochondrial encephalomyopathy characterized clinically by a mixed seizure disorder, myoclonus, progressive ataxia, spasticity, and a mild myopathy. Dysarthria, optic atrophy, growth retardation, deafness, and dementia may also occur. This condition tends to present in childhood and to be transmitted via maternal lineage. Muscle biopsies reveal ragged-red fibers and respiratory chain enzymatic defects. (From Adams et al., Principles of Neurology, 6th ed, p986)

Also Known As: Myoclonic Epilepsy and Ragged Red Fibers; Fukuhara Syndrome; Myoclonus with Epilepsy with Ragged Red Fibers; Myoencephalopathy Ragged-Red Fiber Disease; MERRF Syndromes Show All >>

Networked: 119 relevant articles (0 outcomes, 4 trials/studies) for this Disease

Key Drugs and Agents for MERRF Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Mitochondrial DNA (mtDNA) : 3 studies in 72 results : IBA
  2. Lys Transfer RNA : 1 study in 31 results : IBA
  3. Superoxide Dismutase : 1 study in 2 results : IBA
  4. Zinc : 1 study in 1 result : IBA
  5. Glutathione (Reduced Glutathione) : 1 study in 1 result : IBA
  6. Copper : 1 study in 1 result : IBA
  7. DNA (Deoxyribonucleic Acid) : 10 results : IBA
  8. Mitochondrial encephalopathy : 9 results : IBA
  9. Transfer RNA (tRNA) : 8 results : IBA
  10. lysine- tRNA : 4 results : IBA
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Diseases Related to MERRF Syndrome

  1. Lactic Acidosis
  2. Stroke (Strokes)
  3. Mitochondrial Diseases (Mitochondrial Disease)
  4. Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia)
  5. Myoclonic Epilepsies (Myoclonic Encephalopathy)
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Key Therapies for MERRF Syndrome

Efficacy Chart >>
  1. Epidural Anesthesia : 1 result

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