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Neurofilament Proteins Summary

Description: Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)

Also Known As: Heavy Neurofilament Protein; Neurofilament Triplet Proteins; Neurofilament Protein, Heavy; Protein, Heavy Neurofilament; Proteins, Neurofilament Show All >>

Networked: 188 relevant articles (0 outcomes, 11 trials/studies) for this Bio-Agent

Key Diseases for which Neurofilament Proteins is Relevant

  1. Neoplasms (Cancer) : 2 studies in 33 results
  2. Neuroblastoma : 1 study in 11 results
  3. Parkinson Disease (Parkinson's Disease) : 1 study in 8 results
  4. Motor Neuron Disease (Primary Lateral Sclerosis) : 1 study in 5 results
  5. Medulloblastoma : 1 study in 5 results
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Drugs Related to Neurofilament Proteins

  1. Antibodies
  2. Glial Fibrillary Acidic Protein
  3. Synaptophysin
  4. Autoantibodies
  5. Chromogranin A
  6. Kainic Acid (Kainate)
  7. Immune Sera (Antisera)
  8. Melatonin
  9. Amyloid (Amyloid Fibrils)
  10. Neural Cell Adhesion Molecules (Neural Cell Adhesion Molecule)
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Therapies Related to Neurofilament Proteins

  1. Transplants (Transplant)
  2. Cell Transplantation
  3. Carotid Endarterectomy
  4. Endarterectomy (Thromboendarterectomy)

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