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Primary Ovarian Insufficiency Summary

Description: Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections.

Also Known As: Premature Ovarian Failure; Gonadotropin Resistant Ovary Syndrome; Gonadotropin-Resistant Ovary Syndromes; Insufficiencies, Primary Ovarian; Insufficiency, Primary Ovarian Show All >>

Networked: 870 relevant articles (17 outcomes, 105 trials/studies) for this Disease

Key Drugs and Agents for Primary Ovarian Insufficiency

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Gonadotropin-Releasing Hormone (GnRH) : 2 outcomes 9 studies in 41 results : FDA 2
  2. Estrogens (Estrogen) : 2 outcomes 5 studies in 55 results : FDA 1
  3. Progesterone : 2 outcomes 4 studies in 17 results : FDA 11 Generic
  4. Cyclophosphamide (Cytoxan) : 2 outcomes 1 study in 25 results : FDA 10 Generic
  5. Hormones : 1 outcome 8 studies in 50 results : IBA
  6. Estradiol (Estrace) : 1 outcome 5 studies in 26 results : FDA 44 Generic
  7. Carbon Monoxide : 1 outcome 2 studies in 5 results : IBA
  8. bushen huoxue : 1 outcome 1 study in 4 results : IBA
  9. Medroxyprogesterone Acetate (Depo-Provera) : 1 outcome 1 study in 2 results : FDA 20 Generic
  10. Suppositories (Vaginal Suppositories) : 1 outcome 1 study in 1 result : IBA
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Diseases Related to Primary Ovarian Insufficiency

  1. Breast Neoplasms (Breast Cancer)
  2. Infertility (Sterility)
  3. Systemic Lupus Erythematosus (Libman-Sacks Disease)
  4. Diabetes Mellitus
  5. Immune System Diseases (Immune Disorders)
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Key Therapies for Primary Ovarian Insufficiency

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 4 outcomes 9 studies in 142 results
  2. Hormone Replacement Therapy (Therapy, Hormone Replacement) : 2 outcomes 7 studies in 34 results
  3. Transplantation (Transplant Recipients) : 1 outcome 3 studies in 16 results
  4. Estrogen Replacement Therapy : 1 outcome 1 study in 10 results
  5. Ovariectomy (Oophorectomy) : 1 outcome 1 study in 9 results
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