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Motor Neuron Disease (Primary Lateral Sclerosis) Summary

Description: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)

Also Known As: Primary Lateral Sclerosis; Motor System Disease; Motor Neuron Diseases; Lateral Sclerosis; Motor Neuron Disease, Familial Show All >>

Networked: 1250 relevant articles (34 outcomes, 108 trials/studies) for this Disease

Key Drugs and Agents for Motor Neuron Disease

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Biological Markers (Surrogate Marker) : 3 outcomes 2 studies in 14 results : IBA
  2. Antibodies : 2 outcomes 6 studies in 76 results : IBA
  3. Ciliary Neurotrophic Factor (CNTF) : 2 outcomes 6 studies in 19 results : IBA
  4. Riluzole : 2 outcomes 3 studies in 20 results : FDA 4 Generic
  5. Dyneins (Dynein) : 2 outcomes 3 studies in 16 results : IBA
  6. Brain-Derived Neurotrophic Factor (BDNF) : 1 outcome 3 studies in 16 results : IBA
  7. Proteins (Proteins, Gene) : 1 outcome 2 studies in 44 results : IBA
  8. Glutamic Acid (Glutamate) : 1 outcome 2 studies in 16 results : FDA 7
  9. Gangliosides : 1 outcome 2 studies in 15 results : IBA
  10. Histone Deacetylase Inhibitors : 1 outcome 2 studies in 5 results : IBA
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Diseases Related to Motor Neuron Disease

  1. Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
  2. Nervous System Diseases (Neurological Disorders)
  3. Parkinson Disease (Parkinson's Disease)
  4. Disease Progression
  5. Stroke (Strokes)
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Key Therapies for Motor Neuron Disease

Efficacy Chart >>
  1. Denervation : 1 outcome 4 studies in 23 results
  2. Drug Therapy (Chemotherapy) : 1 outcome 1 study in 7 results
  3. Transplantation (Transplant Recipients) : 1 outcome 1 study in 5 results
  4. Muscle Denervation : 1 outcome 1 study in 3 results
  5. Gastrostomy : 1 outcome in 6 results
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