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Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor) Summary

Description: A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).

Also Known As: Basic Fibroblast Growth Factor; FGF 2; FGF2; Fibroblast Growth Factor, Basic; Cartilage-Derived Growth Factor Show All >>

Networked: 3927 relevant articles (111 outcomes, 542 trials/studies) for this Bio-Agent

Key Diseases for which Fibroblast Growth Factor 2 is Relevant

  1. Wounds and Injuries (Trauma) : 12 outcomes 36 studies in 241 results
  2. Neoplasms (Cancer) : 11 outcomes 75 studies in 774 results
  3. Ischemia : 11 outcomes 21 studies in 142 results
  4. Ulcer : 5 outcomes 7 studies in 54 results
  5. Myocardial Infarction : 4 outcomes 10 studies in 50 results
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Drugs Related to Fibroblast Growth Factor 2

  1. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
  2. Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
  3. Intercellular Signaling Peptides and Proteins (Growth Factors)
  4. Messenger RNA (mRNA)
  5. Platelet-Derived Growth Factor
  6. DNA (Deoxyribonucleic Acid)
  7. Hepatocyte Growth Factor (Growth Factor, Hepatocyte)
  8. Insulin (Novolin)
  9. Cytokines
  10. Heparin (Liquaemin)
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Therapies Related to Fibroblast Growth Factor 2

  1. Transplantation (Transplant Recipients)
  2. Injections
  3. Skin Transplantation (Skin Grafting)
  4. Radiotherapy
  5. Drug Therapy (Chemotherapy)
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