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Cyclins Summary

Description: A large family of regulatory proteins that function as accessory subunits to a variety of CYCLIN-DEPENDENT KINASES. They generally function as ENZYME ACTIVATORS that drive the CELL CYCLE through transitions between phases. A subset of cyclins may also function as transcriptional regulators.

Also Known As: Cyclin

Networked: 3646 relevant articles (40 outcomes, 348 trials/studies) for this Bio-Agent

Key Diseases for which Cyclins is Relevant

  1. Neoplasms (Cancer) : 15 outcomes 111 studies in 1390 results
  2. Retinoblastoma (Glioblastoma, Retinal) : 2 outcomes 9 studies in 269 results
  3. Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) : 2 outcomes 5 studies in 33 results
  4. Multiple Myeloma : 2 outcomes 4 studies in 29 results
  5. Pancreatic Neoplasms (Pancreatic Cancer) : 2 outcomes 4 studies in 22 results
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Drugs Related to Cyclins

  1. Phosphotransferases (Kinase)
  2. Cyclin D1
  3. roscovitine
  4. flavopiridol
  5. Proliferating Cell Nuclear Antigen (PCNA)
  6. Messenger RNA (mRNA)
  7. NF-kappa B (NF-kB)
  8. Biological Markers (Surrogate Marker)
  9. Curcumin
  10. Metformin (Glucophage)
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Therapies Related to Cyclins

  1. Heterologous Transplantation (Xenotransplantation)
  2. Drug Therapy (Chemotherapy)
  3. Chemoprevention
  4. Aftercare (After-Treatment)
  5. Transplants (Transplant)
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