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N-Methyl-D-Aspartate Receptors (NMDA Receptors) Summary

Description: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.

Also Known As: NMDA Receptors; Receptors, N-Methyl-D-Aspartate; N-Methylaspartate Receptors; Receptors, N-Methylaspartate; N Methyl D Aspartate Receptors Show All >>

Networked: 2157 relevant articles (56 outcomes, 188 trials/studies) for this Bio-Agent

Key Diseases for which N-Methyl-D-Aspartate Receptors is Relevant

  1. Seizures (Seizure) : 10 outcomes 19 studies in 227 results
  2. Pain (Aches) : 6 outcomes 20 studies in 236 results
  3. Schizophrenia (Dementia Praecox) : 5 outcomes 22 studies in 226 results
  4. Ischemia : 3 outcomes 11 studies in 134 results
  5. Neuralgia (Stump Neuralgia) : 3 outcomes 7 studies in 73 results
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Drugs Related to N-Methyl-D-Aspartate Receptors

  1. N-Methylaspartate (NMDA)
  2. Glutamic Acid (Glutamate)
  3. Dizocilpine Maleate (Dizocilpine)
  4. Ketamine
  5. Calcium
  6. Memantine (Namenda)
  7. Magnesium
  8. Levodopa (L Dopa)
  9. Ammonia
  10. AMPA Receptors (AMPA Receptor)
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Therapies Related to N-Methyl-D-Aspartate Receptors

  1. Analgesia
  2. Intradermal Injections
  3. Ligation
  4. Intramuscular Injections
  5. Injections
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