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Holoprosencephaly (Arhinencephaly) Summary

117 relevant articles (1 outcomes, 4 trials/studies) found for this Disease

Description: Anterior midline brain, cranial, and facial malformations resulting from the failure of the embryonic prosencephalon to undergo segmentation and cleavage. Alobar prosencephaly is the most severe form and features anophthalmia; cyclopia; severe MENTAL RETARDATION; CLEFT LIP; CLEFT PALATE; SEIZURES; and microcephaly. Semilobar holoprosencepaly is characterized by hypotelorism, microphthalmia, coloboma, nasal malformations, and variable degrees of mental retardation. Lobar holoprosencephaly is associated with mild (or absent) facial malformations and intellectual abilities that range from mild mental retardation to normal. Holoprosencephaly is associated with CHROMOSOME ABNORMALITIES.

Also Known As: Arhinencephaly; Alobar Holoprosencephalies; Arhinencephalies; Holoprosencephalies; Holoprosencephalies, Alobar Show All >>

Key Drugs and Agents for Holoprosencephaly

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Cholesterol : 1 study in 10 results : IBA
  2. trans- 1,4- Bis(2- chlorobenzaminomethyl)cyclohexane Dihydrochloride : 1 study in 6 results : IBA
  3. cyclopamine : 1 study in 5 results : IBA
  4. p-Aminosalicylic Acid (PAS) : 1 study in 1 result : FDA 1
  5. Ethanol (Ethyl Alcohol) : 7 results : IBA
  6. Transcription Factors (Transcription Factor) : 6 results : IBA
  7. Minocycline (Cyclops) : 4 results : FDA 21 Generic
  8. Dihydrotachysterol (AT 10) : 4 results : IBA
  9. tranilast (N 5') : 4 results : IBA
  10. LDL-Receptor Related Protein 2 : 3 results : IBA
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Diseases Related to Holoprosencephaly

  1. Paralysis (Palsy)
  2. Epiglottitis
  3. Apnea
  4. Neuronal Migration Disorders
  5. Syndrome
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Key Therapies for Holoprosencephaly

Efficacy Chart >>
  1. Tracheotomy : 1 outcome in 1 result
  2. Sutures (Suture) : 6 results
  3. Colonic Pouches (S Pouch) : 2 results
  4. Ventriculoperitoneal Shunt : 2 results
  5. Induced Abortion (Induced Abortions) : 2 results
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