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Complement Membrane Attack Complex (Membrane Attack Complex) Summary

Description: A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.

Also Known As: Membrane Attack Complex; C 5b-9; C5b-8-poly-C9; C5b-9; Cytolytic Terminal Complement Complex Show All >>

Networked: 672 relevant articles (3 outcomes, 52 trials/studies) for this Bio-Agent

Key Diseases for which Complement Membrane Attack Complex is Relevant

  1. Inflammation : 1 outcome 2 studies in 55 results
  2. Systemic Lupus Erythematosus (Libman-Sacks Disease) : 1 outcome 1 study in 11 results
  3. Infection : 1 outcome in 16 results
  4. Membranous Glomerulonephritis (Membranous Nephropathy) : 7 studies in 66 results
  5. Proteinuria : 3 studies in 57 results
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Drugs Related to Complement Membrane Attack Complex

  1. Proteins (Proteins, Gene)
  2. Complement System Proteins (Complement)
  3. Antigen-Antibody Complex (Immune Complex)
  4. Complement Membrane Attack Complex (Membrane Attack Complex)
  5. Vitronectin
  6. Monoclonal Antibodies
  7. Antigens
  8. Immunoglobulin G (IgG)
  9. CD59 Antigens
  10. Anaphylatoxins
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Therapies Related to Complement Membrane Attack Complex

  1. Kidney Transplantation
  2. Heterologous Transplantation (Xenotransplantation)
  3. Transplants (Transplant)
  4. Lasers (Laser)
  5. Ligation
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