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Mifepristone (RU 486) Summary

Description: A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.

Also Known As: RU 486; Mifeprex; RU-486; RU486; Mifegyne Show All >>

Networked: 1192 relevant articles (111 outcomes, 190 trials/studies) for this Drug

Key Diseases for which Mifepristone is Relevant

  1. Hemorrhage : 16 outcomes 19 studies in 136 results
  2. Leiomyoma (Uterine Fibroids) : 14 outcomes 18 studies in 58 results
  3. Neoplasms (Cancer) : 12 outcomes 17 studies in 125 results
  4. Cushing Syndrome : 10 outcomes 10 studies in 59 results
  5. Endometriosis (Adenomyosis) : 7 outcomes 8 studies in 44 results
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Drugs Related to Mifepristone

  1. Misoprostol (Cytotec)
  2. Glucocorticoid Receptors (Glucocorticoid Receptor)
  3. Progesterone Receptors (Progesterone Receptor)
  4. Progesterone
  5. Tamoxifen
  6. Estrogen Receptor Modulators (Antiestrogen)
  7. Gonadotropin-Releasing Hormone (GnRH)
  8. asoprisnil
  9. Alprostadil (Muse)
  10. Mifepristone (RU 486)
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Therapies Related to Mifepristone

  1. Aftercare (After-Treatment)
  2. Drug Therapy (Chemotherapy)
  3. Heterologous Transplantation (Xenotransplantation)
  4. Pessaries
  5. Chemoprevention
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