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Lambert-Eaton Myasthenic Syndrome (Lambert-Eaton Syndrome) Summary

Description: An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)

Also Known As: Lambert-Eaton Syndrome; Eaton Lambert Syndrome; Syndrome, Lambert-Eaton; Syndrome, Lambert-Eaton Myasthenic; Eaton-Lambert Myasthenic Syndrome Show All >>

Networked: 457 relevant articles (28 outcomes, 20 trials/studies) for this Disease

Key Drugs and Agents for Lambert-Eaton Myasthenic Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Intravenous Immunoglobulins (IVIG) : 8 outcomes 6 studies in 18 results : FDA 1
  2. 3,4-diaminopyridine : 8 outcomes 5 studies in 28 results : IBA
  3. Immunoglobulins (Immunoglobulin) : 4 outcomes 2 studies in 17 results : IBA
  4. Antibodies : 2 outcomes 2 studies in 134 results : IBA
  5. Guanidine (Guanidine Nitrate) : 2 outcomes 1 study in 8 results : FDA 1
  6. Pyridostigmine Bromide (Pyridostigmine) : 2 outcomes in 6 results : FDA 10 Generic
  7. Calcium Channels (Calcium Channel) : 1 outcome 3 studies in 138 results : IBA
  8. Autoantibodies : 1 outcome 1 study in 69 results : IBA
  9. Immunoglobulin M (IgM) : 1 outcome 1 study in 4 results : IBA
  10. Immunoglobulin G (IgG) : 1 outcome in 48 results : IBA
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Diseases Related to Lambert-Eaton Myasthenic Syndrome

  1. Paraneoplastic Cerebellar Degeneration
  2. Neoplasms (Cancer)
  3. Stiff-Person Syndrome (Stiff Man Syndrome)
  4. Myasthenia Gravis
  5. Dermatomyositis (Dermatopolymyositis)
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Key Therapies for Lambert-Eaton Myasthenic Syndrome

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 5 outcomes in 14 results
  2. Plasma Exchange : 2 outcomes in 6 results
  3. Immunomodulation : 1 outcome in 3 results
  4. Radiotherapy : 1 outcome in 1 result
  5. Aftercare (After-Treatment) : 1 outcome in 1 result
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