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Lambert-Eaton Myasthenic Syndrome (Lambert-Eaton Syndrome) Summary

344 relevant articles (19 outcomes, 15 trials/studies) found for this Disease

Description: An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)

Also Known As: Lambert-Eaton Syndrome; Eaton Lambert Syndrome; Syndrome, Lambert-Eaton; Syndrome, Lambert-Eaton Myasthenic; Eaton-Lambert Myasthenic Syndrome Show All >>

Key Drugs and Agents for Lambert-Eaton Myasthenic Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Intravenous Immunoglobulins (IVIG) : 6 outcomes 4 studies in 12 results : FDA 1
  2. 3,4-diaminopyridine : 5 outcomes 3 studies in 19 results : IBA
  3. Immunoglobulins (Immunoglobulin) : 3 outcomes 2 studies in 15 results : IBA
  4. Guanidine (Guanidine Nitrate) : 2 outcomes 1 study in 8 results : FDA 1
  5. Antibodies : 1 outcome 2 studies in 101 results : IBA
  6. Immunoglobulin M (IgM) : 1 outcome 1 study in 4 results : IBA
  7. Autoantibodies : 1 outcome in 58 results : IBA
  8. Immunoglobulin G (IgG) : 1 outcome in 46 results : IBA
  9. Pyridostigmine Bromide (Pyridostigmine) : 1 outcome in 4 results : FDA 10 Generic
  10. Prednisolone (Predate) : 1 outcome in 4 results : FDA 54 Generic
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Diseases Related to Lambert-Eaton Myasthenic Syndrome

  1. Syndrome
  2. Polyneuropathies (Polyneuropathy)
  3. Dermatomyositis (Dermatopolymyositis)
  4. Stiff-Person Syndrome (Stiff Man Syndrome)
  5. Myasthenia Gravis
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Key Therapies for Lambert-Eaton Myasthenic Syndrome

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 3 outcomes in 11 results
  2. Plasma Exchange : 2 outcomes in 5 results
  3. Electrodes (Electrode) : 1 study in 1 result
  4. Plasmapheresis : 4 results
  5. General Anesthesia : 2 results
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