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Sinus Histiocytosis (Rosai-Dorfman Disease) Summary

Description: Benign, non-Langerhans-cell, histiocytic proliferative disorder that primarily affects the lymph nodes. It is often referred to as sinus histiocytosis with massive lymphadenopathy.

Also Known As: Rosai-Dorfman Disease; Histiocytosis, Sinus; Sinus Histiocytosis with Massive Lymphadenopathy; Destombes Rosai Dorfman Syndrome; Disease, Rosai-Dorfman Show All >>

Networked: 185 relevant articles (12 outcomes, 6 trials/studies) for this Disease

Key Drugs and Agents for Sinus Histiocytosis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Adrenal Cortex Hormones (Corticosteroids) : 3 outcomes in 3 results : IBA
  2. Methotrexate (Mexate) : 2 outcomes in 6 results : FDA 8 Generic
  3. Thalidomide (Thalomid) : 2 outcomes in 4 results : FDA 2
  4. Acitretin : 2 outcomes in 3 results : FDA 1
  5. Muramidase (Lysozyme) : 1 outcome 1 study in 3 results : IBA
  6. Cladribine : 1 outcome in 4 results : FDA 3 Generic
  7. Interferon-alpha (Interferon Alfa) : 1 outcome in 4 results : FDA 2
  8. Steroids : 1 outcome in 3 results : IBA
  9. Anti-Bacterial Agents (Antibiotics) : 1 outcome in 1 result : IBA
  10. imatinib (Gleevec) : 1 outcome in 1 result : FDA 3
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Diseases Related to Sinus Histiocytosis

  1. Histiocytic Necrotizing Lymphadenitis (Kikuchi Disease)
  2. Hodgkin Disease (Hodgkin's Disease)
  3. Paraparesis
  4. Non-Langerhans-Cell Histiocytosis (Histiocytosis, Non Langerhans Cell)
  5. Optic Nerve Diseases (Optic Neuropathy)
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Key Therapies for Sinus Histiocytosis

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 3 outcomes in 7 results
  2. Radiotherapy : 1 outcome in 7 results
  3. Radical Mastectomy : 3 results
  4. Joint Prosthesis : 2 results
  5. Transplants (Transplant) : 1 result
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