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Rett Syndrome (Rett's Disorder) Summary

Description: An inherited neurological developmental disorder that is associated with X-LINKED INHERITANCE and may be lethal in utero to hemizygous males. The affected female is normal until the age of 6-25 months when progressive loss of voluntary control of hand movements and communication skills; ATAXIA; SEIZURES; autistic behavior; intermittent HYPERVENTILATION; and HYPERAMMONEMIA appear. (From Menkes, Textbook of Child Neurology, 5th ed, p199)

Also Known As: Rett's Disorder; Syndrome, Rett; Rett's Syndrome; Autism Dementia Ataxia Loss of Purposeful Hand Use Syndrome; Cerebroatrophic Hyperammonemia Show All >>

Networked: 894 relevant articles (16 outcomes, 79 trials/studies) for this Disease

Key Drugs and Agents for Rett Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. beta-Endorphin (Endorphin, beta) : 2 outcomes 1 study in 8 results : IBA
  2. Naltrexone (ReVia) : 2 outcomes 1 study in 3 results : FDA 7 Generic
  3. Brain-Derived Neurotrophic Factor (BDNF) : 2 outcomes in 32 results : IBA
  4. Methyl-CpG-Binding Protein 2 : 1 outcome 14 studies in 360 results : IBA
  5. Biogenic Amines (Biogenic Amine) : 1 outcome 4 studies in 15 results : IBA
  6. Folic Acid (Vitamin M) : 1 outcome 2 studies in 9 results : FDA 50 Generic
  7. Carnitine (L-Carnitine) : 1 outcome 2 studies in 7 results : FDA 9 Generic
  8. Buspirone (Buspar) : 1 outcome 1 study in 3 results : FDA 16 Generic
  9. MicroRNAs (MicroRNA) : 1 outcome in 4 results : IBA
  10. Biotin (Vitamin H) : 1 outcome in 3 results : FDA 13
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Diseases Related to Rett Syndrome

  1. Autistic Disorder (Autism)
  2. Tuberous Sclerosis (Bourneville's Disease)
  3. Down Syndrome (Down's Syndrome)
  4. Pervasive Child Development Disorders
  5. Prader-Willi Syndrome (Syndrome, Prader-Willi)
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Key Therapies for Rett Syndrome

Efficacy Chart >>
  1. Therapeutics : 1 outcome in 6 results
  2. Splints : 5 studies in 8 results
  3. Self-Help Devices (Assistive Technology) : 1 study in 2 results
  4. Dilatation and Curettage (D&C) : 1 study in 1 result
  5. Cholecystectomy : 1 study in 1 result
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