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Tropical Spastic Paraparesis (Tropical Spastic Paraplegia) Summary

Description: A subacute paralytic myeloneuropathy occurring endemically in tropical areas such as the Caribbean, Colombia, India, and Africa, as well as in the southwestern region of Japan; associated with infection by HUMAN T-CELL LEUKEMIA VIRUS I. Clinical manifestations include a slowly progressive spastic weakness of the legs, increased reflexes, Babinski signs, incontinence, and loss of vibratory and position sensation. On pathologic examination inflammatory, demyelination, and necrotic lesions may be found in the spinal cord. (Adams et al., Principles of Neurology, 6th ed, p1239)

Also Known As: Tropical Spastic Paraplegia; Paraparesis, Tropical Spastic; HTLV I Associated Myelopathies; HTLV-I-Associated Myelopathy-Tropical Spastic Paraparesis; Human T-Lymphotropic Virus Type 1 Associated Myelopathy Show All >>

Networked: 353 relevant articles (14 outcomes, 25 trials/studies) for this Disease

Key Drugs and Agents for Tropical Spastic Paraparesis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Interferon-alpha (Interferon Alfa) : 3 outcomes 3 studies in 14 results : FDA 2
  2. Interferons : 2 outcomes 1 study in 8 results : IBA
  3. Prednisolone (Predate) : 2 outcomes 1 study in 4 results : FDA 55 Generic
  4. Messenger RNA (mRNA) : 1 outcome 1 study in 10 results : IBA
  5. Pentoxifylline (Trental) : 1 outcome 1 study in 4 results : FDA 11 Generic
  6. prosultiamine : 1 outcome 1 study in 3 results : IBA
  7. Valproic Acid (Valproate, Semisodium) : 1 outcome 1 study in 2 results : FDA 51 Generic
  8. Ascorbic Acid (Vitamin C) : 1 outcome 1 study in 2 results : FDA 18 Generic
  9. Danazol (Azol) : 1 outcome in 4 results : FDA 5 Generic
  10. 14-3-3 Proteins (14-3-3 Protein) : 1 outcome in 1 result : IBA
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Diseases Related to Tropical Spastic Paraparesis

  1. Spinal Cord Diseases
  2. Tropical Spastic Paraparesis (Tropical Spastic Paraplegia)
  3. T-Cell Leukemia (Leukemia, T Cell)
  4. Lymphoma (Lymphomas)
  5. Cerebral Infarction
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Key Therapies for Tropical Spastic Paraparesis

Efficacy Chart >>
  1. Plasmapheresis : 1 outcome in 1 result
  2. Oral Administration : 2 studies in 2 results
  3. Blood Transfusion (Blood Transfusions) : 1 study in 11 results
  4. Transplants (Transplant) : 3 results
  5. Kidney Transplantation : 2 results
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