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BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) Summary

6314 relevant articles (510 outcomes, 582 trials/studies) found for this Disease

Description: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.

Also Known As: Chronic Myelogenous Leukemia; Chronic Myeloid Leukemia; Leukemia, Myeloid, Philadelphia Positive; Chronic Granulocytic Leukemia; Leukemia, Chronic Myelogenous Show All >>

Key Drugs and Agents for BCR-ABL Positive Chronic Myelogenous Leukemia

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. imatinib (Gleevec) : 179 outcomes 111 studies in 1226 results : FDA 2
  2. Interferon-alpha (Interferon Alfa) : 72 outcomes 68 studies in 535 results : FDA 1
  3. Protein-Tyrosine Kinases (Tyrosine Kinase) : 33 outcomes 21 studies in 431 results : IBA
  4. Interferons : 30 outcomes 43 studies in 267 results : IBA
  5. Busulfan (Busulfex) : 20 outcomes 20 studies in 231 results : FDA 2
  6. Phosphotransferases (Kinase) : 15 outcomes 7 studies in 232 results : IBA
  7. Bcr-Abl tyrosine kinase : 15 outcomes 6 studies in 144 results : IBA
  8. Cytarabine (Cytosar-U) : 9 outcomes 32 studies in 148 results : FDA 14 Generic
  9. Cyclophosphamide (Cytoxan) : 8 outcomes 7 studies in 74 results : FDA 10
  10. Messenger RNA (mRNA) : 7 outcomes 14 studies in 198 results : IBA
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Diseases Related to BCR-ABL Positive Chronic Myelogenous Leukemia

  1. Leukemia
  2. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
  3. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
  4. Blast Crisis (Blast Phase)
  5. Philadelphia Chromosome
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Key Therapies for BCR-ABL Positive Chronic Myelogenous Leukemia

Efficacy Chart >>
  1. Bone Marrow Transplantation (Transplantation, Bone Marrow) : 58 outcomes 35 studies in 601 results
  2. Transplants (Transplant) : 38 outcomes 15 studies in 343 results
  3. Transplantation (Transplant Recipients) : 23 outcomes 19 studies in 250 results
  4. Drug Therapy (Chemotherapy) : 19 outcomes 14 studies in 261 results
  5. Stem Cell Transplantation : 19 outcomes 11 studies in 173 results
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