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Hereditary Spastic Paraplegia Summary

Description: A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)

Also Known As: Spastic Paraplegia, Hereditary; Autosomal Dominant Hereditary Spastic Paraplegia; Autosomal Dominant Spastic Paraplegia Hereditary; Autosomal Recessive Hereditary Spastic Paraplegia; Autosomal Recessive Spastic Paraplegia, Hereditary Show All >>

Networked: 187 relevant articles (5 outcomes, 9 trials/studies) for this Disease

Key Drugs and Agents for Hereditary Spastic Paraplegia

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Baclofen : 3 outcomes 1 study in 5 results : FDA 31 Generic
  2. Type A Botulinum Toxins (Botulinum A Toxin) : 1 outcome 1 study in 2 results : FDA 2
  3. Ursodeoxycholic Acid (Urso) : 1 outcome in 1 result : FDA 9 Generic
  4. Chenodeoxycholic Acid (Chenix) : 1 outcome in 1 result : FDA 2
  5. Spastic paraplegia 17 : 2 studies in 6 results : IBA
  6. Proteins (Proteins, Gene) : 1 study in 22 results : IBA
  7. Mitochondrial Proteins (Mitochondrial Protein) : 1 study in 6 results : IBA
  8. Levodopa (L Dopa) : 1 study in 4 results : FDA 31 Generic
  9. Pontocerebellar Hypoplasia Type 1 : 1 study in 2 results : IBA
  10. RNA (Ribonucleic Acid) : 1 study in 1 result : IBA
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Diseases Related to Hereditary Spastic Paraplegia

  1. Paraplegia (Spastic Paraplegia)
  2. Atrophy
  3. Muscle Spasticity (Spastic)
  4. Mental Retardation (Idiocy)
  5. Spinocerebellar Ataxias (Spinocerebellar Ataxia)
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Key Therapies for Hereditary Spastic Paraplegia

Efficacy Chart >>
  1. Ligation : 2 results
  2. Injections : 2 results
  3. Drug Therapy (Chemotherapy) : 1 result
  4. Activities of Daily Living (ADL) : 1 result

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