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Neprilysin (Neutral Endopeptidase) Summary

Description: Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.

Also Known As: Neutral Endopeptidase; Atriopeptidase; CD10 Antigen; Enkephalinase-24.11; Neutral Endopeptidase 24.11 Show All >>

Networked: 851 relevant articles (34 outcomes, 98 trials/studies) for this Bio-Agent

Key Diseases for which Neprilysin is Relevant

  1. Heart Failure : 11 outcomes 31 studies in 151 results
  2. Hypertension (High Blood Pressure) : 8 outcomes 17 studies in 99 results
  3. Pulmonary Hypertension (Ayerza Syndrome) : 2 outcomes 1 study in 9 results
  4. Diarrhea : 2 outcomes in 9 results
  5. Alzheimer Disease (Alzheimer's Disease) : 1 outcome 5 studies in 74 results
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Drugs Related to Neprilysin

  1. 3- (1- biphenyl- 4- ylmethyl- 3- ethoxycarbonyl- 1- butylcarbamoyl)propionate- 3'- methyl- 2'- (pentanoyl(2'- (tetrazol- 5- ylate)biphenyl- 4'- ylmethyl)amino)butyrate
  2. Angiotensins
  3. Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
  4. Neprilysin (Neutral Endopeptidase)
  5. Amyloid (Amyloid Fibrils)
  6. valsartan (Vals)
  7. Peptides
  8. Thiorphan
  9. Angiotensin Receptors (Angiotensin II Receptor)
  10. acetorphan (ecadotril)
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Therapies Related to Neprilysin

  1. Injections
  2. Analgesia
  3. Catheters
  4. Cardiac Resynchronization Therapy
  5. Drug-Eluting Stents
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