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Wolfram Syndrome (Syndrome, Wolfram) Summary

Description: A hereditary condition characterized by multiple symptoms including those of DIABETES INSIPIDUS; DIABETES MELLITUS; OPTIC ATROPHY; and DEAFNESS. This syndrome is also known as DIDMOAD (first letter of each word) and is usually associated with VASOPRESSIN deficiency. It is caused by mutations in gene WFS1 encoding wolframin, a 100-kDa transmembrane protein.

Also Known As: Syndrome, Wolfram; Diabetes Insipidus and Mellitus with Optic Atrophy and Deafness; DIDMOAD; DIDMOAD Syndrome

Networked: 119 relevant articles (1 outcomes, 13 trials/studies) for this Disease

Key Drugs and Agents for Wolfram Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. idebenone : 1 outcome in 1 result : IBA
  2. Tungsten : 3 studies in 32 results : IBA
  3. Mitochondrial DNA (mtDNA) : 2 studies in 9 results : IBA
  4. Autoantibodies : 2 studies in 2 results : IBA
  5. Insulin (Novolin) : 1 study in 22 results : FDA 2
  6. Thiamine (Aneurin) : 1 study in 5 results : FDA 6
  7. Vasopressins (Vasopressin) : 1 study in 3 results : IBA
  8. Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase) : 1 study in 1 result : IBA
  9. Transferases : 1 study in 1 result : IBA
  10. Growth Hormone (Somatotropin) : 1 study in 1 result : IBA
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Diseases Related to Wolfram Syndrome

  1. Wolfram Syndrome (Syndrome, Wolfram)
  2. Diabetes Insipidus
  3. Mood Disorders (Mood Disorder)
  4. Anemia
  5. Low Tension Glaucoma
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Key Therapies for Wolfram Syndrome

Efficacy Chart >>
  1. Pancreas Transplantation : 1 result
  2. Kidney Transplantation : 1 result
  3. Vitrectomy : 1 result
  4. Light Coagulation : 1 result

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