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Wernicke Encephalopathy (Wernicke's Encephalopathy) Summary

Description: An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)

Also Known As: Wernicke's Encephalopathy; Wernicke Syndrome; Encephalopathy, Gayet-Wernicke; Encephalopathy, Wernicke's; Gayet-Wernicke Encephalopathy Show All >>

Networked: 387 relevant articles (10 outcomes, 14 trials/studies) for this Disease

Key Drugs and Agents for Wernicke Encephalopathy

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Thiamine (Aneurin) : 8 outcomes 3 studies in 180 results : FDA 6
  2. Transketolase : 1 outcome in 5 results : IBA
  3. Vitamins : 1 study in 17 results : IBA
  4. Glucose (Dextrose) : 1 study in 13 results : FDA 175 Generic
  5. Pyrithiamine : 1 study in 7 results : IBA
  6. Thiamine Pyrophosphate : 1 study in 5 results : IBA
  7. Enzymes : 1 study in 4 results : IBA
  8. Disulfiram (Antabuse) : 1 study in 3 results : FDA 9
  9. Janus Kinase 2 : 1 study in 2 results : IBA
  10. Vitamin B Complex (B Vitamins) : 1 study in 2 results : IBA
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Diseases Related to Wernicke Encephalopathy

  1. Hyperemesis Gravidarum
  2. Vomiting
  3. Beriberi
  4. Neurologic Manifestations (Neurological Manifestations)
  5. Alcohol Withdrawal Delirium (Delirium Tremens)
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Key Therapies for Wernicke Encephalopathy

Efficacy Chart >>
  1. Parenteral Nutrition : 1 outcome in 19 results
  2. Oral Administration : 1 outcome in 2 results
  3. Institutionalization (Institutionalized Persons) : 2 studies in 3 results
  4. Bone Marrow Transplantation (Transplantation, Bone Marrow) : 1 study in 1 result
  5. Bariatric Surgery : 20 results
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