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Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) Summary

Description: A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)

Also Known As: Steele Richardson Olszewski Syndrome; Progressive Supranuclear Ophthalmoplegia; Supranuclear Palsy, Progressive; Palsy, Progressive Supranuclear; Steele-Richardson-Olszewski Disease Show All >>

Networked: 678 relevant articles (13 outcomes, 85 trials/studies) for this Disease

Key Drugs and Agents for Progressive Supranuclear Palsy

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Citric Acid (Citrate) : 2 outcomes in 3 results : FDA 10 Generic
  2. tandospirone : 2 outcomes in 3 results : IBA
  3. tau Proteins (tau Protein) : 1 outcome 6 studies in 85 results : IBA
  4. Levodopa (L Dopa) : 1 outcome 4 studies in 51 results : FDA 31 Generic
  5. zolpidem (Ambien) : 1 outcome 2 studies in 6 results : FDA 29 Generic
  6. Silver : 1 outcome 1 study in 9 results : IBA
  7. Adenosine Triphosphate (ATP) : 1 outcome 1 study in 3 results : IBA
  8. Amitriptyline (Elavil) : 1 outcome in 5 results : FDA 198 Generic
  9. Dopamine Agonists (Dopamine Agonist) : 1 outcome in 4 results : IBA
  10. Botulinum Toxins (Botulinum Toxin) : 1 outcome in 3 results : IBA
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Diseases Related to Progressive Supranuclear Palsy

  1. Muscle Rigidity
  2. Paresis (Hemiparesis)
  3. Parkinson Disease (Parkinson's Disease)
  4. Alzheimer Disease (Alzheimer's Disease)
  5. Multiple System Atrophy
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Key Therapies for Progressive Supranuclear Palsy

Efficacy Chart >>
  1. Enteral Nutrition (Feeding, Tube) : 1 study in 2 results
  2. Therapeutics : 1 study in 1 result
  3. Deep Brain Stimulation : 4 results
  4. Transplants (Transplant) : 2 results
  5. Transplantation (Transplant Recipients) : 2 results
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