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Retinoblastoma (Glioblastoma, Retinal) Summary

Description: A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)

Also Known As: Glioblastoma, Retinal; Glioma, Retinal; Neuroblastoma, Retinal; Eye Cancer, Retinoblastoma; Familial Retinoblastoma Show All >>

Networked: 4726 relevant articles (144 outcomes, 422 trials/studies) for this Disease

Key Drugs and Agents for Retinoblastoma

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Carboplatin (JM8) : 19 outcomes 22 studies in 110 results : FDA 29 Generic
  2. Melphalan (Alkeran) : 12 outcomes 8 studies in 70 results : FDA 2 Generic
  3. Vincristine (Oncovin) : 8 outcomes 8 studies in 43 results : FDA 17 Generic
  4. Etoposide (VP 16) : 7 outcomes 9 studies in 47 results : FDA 16 Generic
  5. Cyclin D1 : 5 outcomes 14 studies in 189 results : IBA
  6. Retinoblastoma Protein : 4 outcomes 24 studies in 419 results : IBA
  7. Topotecan (Hycamtin) : 4 outcomes 6 studies in 31 results : FDA 6 Generic
  8. Cyclin D3 : 4 outcomes in 10 results : IBA
  9. Proteins (Proteins, Gene) : 3 outcomes 28 studies in 612 results : IBA
  10. Retinaldehyde (Retinal) : 3 outcomes 24 studies in 248 results : IBA
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Diseases Related to Retinoblastoma

  1. Neoplasms (Cancer)
  2. Neuroblastoma
  3. Neoplasm Metastasis (Metastasis)
  4. Retinal Neoplasms
  5. Retinoblastoma (Glioblastoma, Retinal)
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Key Therapies for Retinoblastoma

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 43 outcomes 38 studies in 467 results
  2. Radiotherapy : 15 outcomes 12 studies in 227 results
  3. Cryotherapy (Therapy, Cold) : 6 outcomes 2 studies in 67 results
  4. Heterologous Transplantation (Xenotransplantation) : 5 outcomes 15 studies in 59 results
  5. Transplants (Transplant) : 4 outcomes in 14 results
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