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Insulin Receptor Summary

Description: A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.

Also Known As: Receptor, Insulin; Insulin Receptor alpha Chain; Insulin Receptor beta Chain; Insulin-Dependent Tyrosine Protein Kinase; Receptors, Insulin Show All >>

Networked: 2700 relevant articles (62 outcomes, 254 trials/studies) for this Bio-Agent

Key Diseases for which Insulin Receptor is Relevant

  1. Insulin Resistance : 20 outcomes 98 studies in 1057 results
  2. Obesity : 5 outcomes 26 studies in 174 results
  3. Neoplasms (Cancer) : 5 outcomes 21 studies in 186 results
  4. Hyperinsulinism (Hyperinsulinemia) : 4 outcomes 13 studies in 163 results
  5. Diabetes Mellitus : 4 outcomes 10 studies in 117 results
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Drugs Related to Insulin Receptor

  1. Insulin (Novolin)
  2. Glucose (Dextrose)
  3. Antibodies
  4. Phosphotransferases (Kinase)
  5. Protein-Tyrosine Kinases (Tyrosine Kinase)
  6. Tyrosine (L-Tyrosine)
  7. Adiponectin
  8. 3- (8- amino- 1- (2- phenylquinolin- 7- yl)imidazo(1,5- a)pyrazin- 3- yl)- 1- methylcyclobutanol
  9. Autoantibodies
  10. Metformin (Glucophage)
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Therapies Related to Insulin Receptor

  1. Gastric Bypass (Roux-en-Y Gastric Bypass)
  2. Heterologous Transplantation (Xenotransplantation)
  3. Carbohydrate-Restricted Diet (Low Carbohydrate Diet)
  4. Caloric Restriction
  5. Renal Dialysis (Hemodialysis)
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