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Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate) Summary

Description: A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

Also Known As: Dehydrogenase Complex, Pyruvate; Complex, Pyruvate Dehydrogenase

Networked: 292 relevant articles (2 outcomes, 21 trials/studies) for this Bio-Agent

Key Diseases for which Pyruvate Dehydrogenase Complex is Relevant

  1. Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) : 1 outcome 7 studies in 98 results
  2. Hemorrhagic Shock : 1 outcome in 1 result
  3. Starvation : 2 studies in 19 results
  4. Leigh Disease (Leigh's Disease) : 1 study in 15 results
  5. Insulin Resistance : 1 study in 8 results
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Drugs Related to Pyruvate Dehydrogenase Complex

  1. Dichloroacetate (Dichloroacetic Acid)
  2. Antibodies
  3. Pyruvic Acid (Pyruvate)
  4. Autoantibodies
  5. Antigens
  6. Glucose (Dextrose)
  7. Dihydrolipoyllysine-Residue Acetyltransferase (Dihydrolipoyl Transacetylase)
  8. Enzymes
  9. Ketoglutarate Dehydrogenase Complex (Oxoglutarate Dehydrogenase)
  10. pyruvate dehydrogenase (acetyl-transferring) kinase (pyruvate dehydrogenase kinase)
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Therapies Related to Pyruvate Dehydrogenase Complex

  1. Ketogenic Diet
  2. Heterologous Transplantation (Xenotransplantation)
  3. Transplantation (Transplant Recipients)
  4. Intramuscular Injections

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