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Protein Kinase C Summary

Description: An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.

Also Known As: Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Protein Kinase M; Calcium Activated Phospholipid Dependent Kinase; Calcium Phospholipid Dependent Protein Kinase; PKC Serine Threonine Kinase Show All >>

Networked: 4783 relevant articles (60 outcomes, 479 trials/studies) for this Bio-Agent

Key Diseases for which Protein Kinase C is Relevant

  1. Ischemia : 7 outcomes 20 studies in 159 results
  2. Neoplasms (Cancer) : 6 outcomes 71 studies in 965 results
  3. Anoxia (Hypoxia) : 4 outcomes 17 studies in 158 results
  4. Diabetic Retinopathy (Retinopathy, Diabetic) : 4 outcomes 9 studies in 38 results
  5. Hypertension (High Blood Pressure) : 3 outcomes 14 studies in 83 results
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Drugs Related to Protein Kinase C

  1. Calcium
  2. Protein Isoforms (Isoforms)
  3. Protein Kinases (Protein Kinase)
  4. Type C Phospholipases
  5. chelerythrine
  6. Phosphatidylinositols (Phosphatidylinositol)
  7. ruboxistaurin
  8. Insulin (Novolin)
  9. Epidermal Growth Factor (EGF)
  10. Adenosine
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Therapies Related to Protein Kinase C

  1. Drug Therapy (Chemotherapy)
  2. Oral Administration
  3. Injections
  4. Combination Drug Therapy (Combination Chemotherapy)
  5. Ligation
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