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Protein C Summary

Description: A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.

Key Diseases for which Protein C is Relevant

  1. Sepsis (Septicemia) : 71 outcomes 168 studies in 678 results
  2. Septic Shock (Toxic Shock Syndrome) : 12 outcomes 23 studies in 136 results
  3. Protein C Deficiency : 9 outcomes 11 studies in 215 results
  4. Inflammation : 8 outcomes 20 studies in 236 results
  5. Hemorrhage : 7 outcomes 21 studies in 99 results
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Drugs Related to Protein C

  1. drotrecogin alfa activated (Xigris)
  2. Antithrombin III
  3. Heparin (Liquaemin)
  4. Protein S
  5. Dacarbazine (DIC)
  6. lipoprotein-associated coagulation inhibitor (TFPI)
  7. Anticoagulants
  8. Antigens
  9. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
  10. Norepinephrine (Noradrenaline)
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Therapies Related to Protein C

  1. Resuscitation
  2. Catheters
  3. Transplants (Transplant)
  4. Artificial Respiration (Mechanical Ventilation)
  5. Transplantation (Transplant Recipients)
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