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Properdin Summary

Description: A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.

Also Known As: Factor P, Complement; Complement Factor P

Networked: 373 relevant articles (6 outcomes, 27 trials/studies) for this Bio-Agent

Key Diseases for which Properdin is Relevant

  1. Infection : 2 outcomes 3 studies in 55 results
  2. Arthritis (Polyarthritis) : 1 outcome in 6 results
  3. Reperfusion Injury : 1 outcome in 2 results
  4. Convalescence : 1 outcome in 2 results
  5. Kidney Diseases (Kidney Disease) : 1 outcome in 1 result
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Drugs Related to Properdin

  1. Complement System Proteins (Complement)
  2. Antigen-Antibody Complex (Immune Complex)
  3. Lipopolysaccharides
  4. Anaphylatoxins
  5. CD55 Antigens (Decay Accelerating Factor)
  6. Collagen
  7. Complement Factor B (Factor B)
  8. Immunoglobulin A (IgA)
  9. Immunoglobulin G (IgG)
  10. Antibodies
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Therapies Related to Properdin

  1. Homologous Transplantation (Allograft)
  2. Radiotherapy
  3. Aftercare (After-Treatment)
  4. Transplants (Transplant)
  5. Ligation
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