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Prader-Willi Syndrome (Syndrome, Prader-Willi) Summary

Description: An autosomal dominant disorder caused by deletion of the proximal long arm of the paternal chromosome 15 (15q11-q13) or by inheritance of both of the pair of chromosomes 15 from the mother (UNIPARENTAL DISOMY) which are imprinted (GENETIC IMPRINTING) and hence silenced. Clinical manifestations include MENTAL RETARDATION; MUSCULAR HYPOTONIA; HYPERPHAGIA; OBESITY; short stature; HYPOGONADISM; STRABISMUS; and HYPERSOMNOLENCE. (Menkes, Textbook of Child Neurology, 5th ed, p229)

Also Known As: Syndrome, Prader-Willi; Labhart Willi Syndrome; Labhart-Willi-Prader-Fanconi Syndrome; Prader Labhart Willi Syndrome; Royer's Syndrome Show All >>

Networked: 747 relevant articles (21 outcomes, 64 trials/studies) for this Disease

Key Drugs and Agents for Prader-Willi Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Growth Hormone (Somatotropin) : 10 outcomes 24 studies in 212 results : IBA
  2. Oxytocin (Pitocin) : 1 outcome 2 studies in 10 results : FDA 7 Generic
  3. Human Growth Hormone (Saizen) : 1 outcome 1 study in 16 results : FDA 15 Generic
  4. modafinil (armodafinil) : 1 outcome 1 study in 2 results : FDA 10
  5. Gonadal Steroid Hormones (Sex Hormones) : 1 outcome 1 study in 1 result : IBA
  6. Mazindol (Mazanor) : 1 outcome in 3 results : FDA 2
  7. Guanfacine (Tenex) : 1 outcome in 1 result : FDA 7 Generic
  8. Tryptophan (L-Tryptophan) : 1 outcome in 1 result : FDA 30
  9. Deuterium : 1 outcome in 1 result : IBA
  10. Appetite Depressants (Anorectics) : 1 outcome in 1 result : IBA
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Diseases Related to Prader-Willi Syndrome

  1. Morbid Obesity
  2. Obesity
  3. Hyperphagia
  4. Insulin Resistance
  5. Sleep Apnea Syndromes (Sleep Apnea)
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Key Therapies for Prader-Willi Syndrome

Efficacy Chart >>
  1. Gastric Bypass (Roux-en-Y Gastric Bypass) : 1 outcome in 3 results
  2. Gastrectomy : 1 outcome in 3 results
  3. Transplantation (Transplant Recipients) : 1 study in 1 result
  4. Psychophysiology (Physiological Psychology) : 1 study in 1 result
  5. Language Therapy (Language Training) : 1 study in 1 result
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