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Porphyrias Summary

Description: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.

Also Known As: Porphyria

Networked: 1291 relevant articles (26 outcomes, 81 trials/studies) for this Disease

Key Drugs and Agents for Porphyrias

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Hexachlorobenzene (HCB) : 3 outcomes 24 studies in 157 results : IBA
  2. Glucose (Dextrose) : 3 outcomes 2 studies in 18 results : FDA 175 Generic
  3. Porphyrins : 2 outcomes 12 studies in 178 results : IBA
  4. Chloroquine (Aralen) : 2 outcomes 1 study in 19 results : FDA 1 Generic
  5. Heme (Haem) : 1 outcome 9 studies in 277 results : IBA
  6. Cytochrome P-450 Enzyme System (Cytochrome P450) : 1 outcome 3 studies in 21 results : IBA
  7. Hemin (Panhematin) : 1 outcome 2 studies in 19 results : FDA 1
  8. Muscimol : 1 outcome 1 study in 1 result : IBA
  9. Glycerol (Glycerine) : 1 outcome 1 study in 1 result : FDA 6 Generic
  10. Oxidoreductases : 1 outcome in 6 results : IBA
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Diseases Related to Porphyrias

  1. Hepatic Porphyrias (Hepatic Porphyria)
  2. Porphyria Cutanea Tarda
  3. Erythropoietic Protoporphyria
  4. Pemphigus (Pemphigus Vulgaris)
  5. Skin Diseases
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Key Therapies for Porphyrias

Efficacy Chart >>
  1. Photochemotherapy (Photodynamic Therapy) : 1 outcome in 7 results
  2. Splenectomy : 1 outcome in 5 results
  3. Aftercare (After-Treatment) : 1 outcome in 5 results
  4. Intravenous Injections : 1 outcome in 1 result
  5. Laparotomy : 1 study in 1 result
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