Search Login Register

Philadelphia Chromosome Summary

Description: An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).

Also Known As: Ph 1 Chromosome; 1 Chromosome, Ph; 1 Chromosomes, Ph; Chromosome, Ph 1; Chromosome, Ph1 Show All >>

Networked: 1672 relevant articles (207 outcomes, 161 trials/studies) for this Disease

Key Drugs and Agents for Philadelphia Chromosome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. imatinib (Gleevec) : 75 outcomes 75 studies in 507 results : FDA 3
  2. Protein-Tyrosine Kinases (Tyrosine Kinase) : 27 outcomes 13 studies in 243 results : IBA
  3. dasatinib (BMS 354825) : 23 outcomes 17 studies in 136 results : FDA 2
  4. Interferon-alpha (Interferon Alfa) : 14 outcomes 13 studies in 87 results : FDA 2
  5. Bcr-Abl tyrosine kinase : 10 outcomes 2 studies in 68 results : IBA
  6. 4- methyl- N- (3- (4- methylimidazol- 1- yl)- 5- (trifluoromethyl)phenyl)- 3- ((4- pyridin- 3- ylpyrimidin- 2- yl)amino)benzamide (nilotinib) : 9 outcomes 17 studies in 59 results : FDA 1
  7. Phosphotransferases (Kinase) : 7 outcomes 4 studies in 101 results : IBA
  8. Busulfan (Busulfex) : 4 outcomes 3 studies in 24 results : FDA 2
  9. Messenger RNA (mRNA) : 4 outcomes 1 study in 62 results : IBA
  10. Interferons : 3 outcomes 7 studies in 33 results : IBA
Show All >>

Diseases Related to Philadelphia Chromosome

  1. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
  2. BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
  3. Leukemia
  4. Residual Neoplasm
  5. Chromosome Aberrations (Chromosome Abnormalities)
Show All >>

Key Therapies for Philadelphia Chromosome

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 34 outcomes 14 studies in 154 results
  2. Stem Cell Transplantation : 15 outcomes 8 studies in 53 results
  3. Transplantation (Transplant Recipients) : 14 outcomes 4 studies in 60 results
  4. Bone Marrow Transplantation (Transplantation, Bone Marrow) : 12 outcomes 7 studies in 68 results
  5. Hematopoietic Stem Cell Transplantation : 9 outcomes 2 studies in 54 results
Show All >>

CureHunter Inc. provides medical information and specifically does NOT provide medical advice.
© Copyright 2003-2016 CureHunter Inc., MeSH copyright NLM, Journal Articles copyright original owners.