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Parkinson Disease (Parkinson's Disease) Summary

Description: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

Also Known As: Parkinson's Disease; Idiopathic Parkinson's Disease; Parkinsonism, Primary; Lewy Body Parkinson's Disease; Parkinson Disease, Idiopathic Show All >>

Networked: 30777 relevant articles (1919 outcomes, 4103 trials/studies) for this Disease

Key Drugs and Agents for Parkinson Disease

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Levodopa (L Dopa) : 483 outcomes 695 studies in 4869 results : FDA 31 Generic
  2. Dopamine (Intropin) : 146 outcomes 330 studies in 3807 results : FDA 36 Generic
  3. Dopamine Agonists (Dopamine Agonist) : 78 outcomes 136 studies in 961 results : IBA
  4. 1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP) : 52 outcomes 197 studies in 1272 results : IBA
  5. pramipexol (pramipexole) : 41 outcomes 86 studies in 273 results : FDA 1 Generic
  6. Apomorphine : 41 outcomes 50 studies in 397 results : IBA
  7. Selegiline (E250) : 39 outcomes 94 studies in 457 results : FDA 17 Generic
  8. Glial Cell Line-Derived Neurotrophic Factor (GDNF) : 39 outcomes 62 studies in 329 results : IBA
  9. Bromocriptine (Parlodel) : 34 outcomes 63 studies in 287 results : FDA 8 Generic
  10. rasagiline (Azilect) : 29 outcomes 62 studies in 170 results : FDA 1
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Diseases Related to Parkinson Disease

  1. Dyskinesias (Dyskinesia)
  2. Alzheimer Disease (Alzheimer's Disease)
  3. Neurodegenerative Diseases (Neurodegenerative Disease)
  4. Tremor (Tremors)
  5. Dementia (Dementias)
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Key Therapies for Parkinson Disease

Efficacy Chart >>
  1. Deep Brain Stimulation : 247 outcomes 182 studies in 2051 results
  2. Transplantation (Transplant Recipients) : 53 outcomes 96 studies in 652 results
  3. Activities of Daily Living (ADL) : 53 outcomes 35 studies in 332 results
  4. Pallidotomy : 34 outcomes 40 studies in 328 results
  5. Transplants (Transplant) : 31 outcomes 70 studies in 422 results
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