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Neuroblastoma Summary

Description: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Also Known As: Neuroblastomas

Networked: 17756 relevant articles (606 outcomes, 2411 trials/studies) for this Disease

Key Drugs and Agents for Neuroblastoma

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. 3-Iodobenzylguanidine (Iobenguane) : 33 outcomes 67 studies in 427 results : IBA
  2. Cisplatin (Platino) : 16 outcomes 30 studies in 216 results : FDA 6 Generic
  3. Etoposide (VP 16) : 16 outcomes 27 studies in 155 results : FDA 16 Generic
  4. Cyclophosphamide (Cytoxan) : 16 outcomes 25 studies in 142 results : FDA 10 Generic
  5. DNA (Deoxyribonucleic Acid) : 12 outcomes 41 studies in 520 results : IBA
  6. Hydrogen Peroxide (Hydroperoxide) : 12 outcomes 30 studies in 127 results : FDA 1 Generic
  7. Topotecan (Hycamtin) : 11 outcomes 16 studies in 73 results : FDA 6 Generic
  8. Tretinoin (Retinoic Acid) : 9 outcomes 61 studies in 661 results : FDA 27 Generic
  9. Amyloid (Amyloid Fibrils) : 9 outcomes 46 studies in 325 results : IBA
  10. Interleukin-2 (IL2) : 9 outcomes 20 studies in 95 results : IBA
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Diseases Related to Neuroblastoma

  1. Neoplasms (Cancer)
  2. Neoplasm Metastasis (Metastasis)
  3. Neuroblastoma
  4. Carcinoma (Carcinomatosis)
  5. Glioma (Gliomas)
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Key Therapies for Neuroblastoma

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 97 outcomes 108 studies in 873 results
  2. Heterologous Transplantation (Xenotransplantation) : 30 outcomes 56 studies in 401 results
  3. Immunotherapy : 19 outcomes 10 studies in 122 results
  4. Radiotherapy : 17 outcomes 18 studies in 188 results
  5. Bone Marrow Transplantation (Transplantation, Bone Marrow) : 17 outcomes 18 studies in 155 results
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