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Narcolepsy Summary

Description: A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)

Also Known As: Gelineau's Syndrome; Narcoleptic Syndrome; Gelineau's Syndromes; Gelineaus Syndrome; Narcolepsy Cataplexy Syndrome Show All >>

Networked: 1578 relevant articles (99 outcomes, 218 trials/studies) for this Disease

Key Drugs and Agents for Narcolepsy

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. modafinil (armodafinil) : 39 outcomes 31 studies in 200 results : FDA 10
  2. Sodium Oxybate (gamma Hydroxybutyrate) : 27 outcomes 25 studies in 126 results : FDA 1
  3. Methylphenidate (Ritalin) : 6 outcomes 3 studies in 61 results : FDA 25 Generic
  4. Antidepressive Agents (Antidepressants) : 4 outcomes 7 studies in 30 results : IBA
  5. orexins (orexin) : 3 outcomes 58 studies in 625 results : IBA
  6. Amphetamines : 3 outcomes 3 studies in 13 results : IBA
  7. Intravenous Immunoglobulins (IVIG) : 3 outcomes 2 studies in 9 results : FDA 1
  8. Baclofen : 3 outcomes 2 studies in 6 results : FDA 31 Generic
  9. Clomipramine (Anafranil) : 3 outcomes in 9 results : FDA 9 Generic
  10. GABA-B Receptors (Receptor, GABA-B) : 3 outcomes in 4 results : IBA
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Diseases Related to Narcolepsy

  1. Cataplexy
  2. Disorders of Excessive Somnolence (Hypersomnia)
  3. Obstructive Sleep Apnea
  4. Circadian Rhythm Sleep Disorders (Delayed Sleep Phase Syndrome)
  5. Idiopathic Hypersomnolence
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Key Therapies for Narcolepsy

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 1 outcome 1 study in 15 results
  2. Transplantation (Transplant Recipients) : 1 outcome 1 study in 1 result
  3. Immunotherapy : 1 outcome in 4 results
  4. Aftercare (After-Treatment) : 1 outcome in 4 results
  5. Renal Dialysis (Hemodialysis) : 1 outcome in 2 results
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