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Myotonic Dystrophy (Dystrophia Myotonica) Summary

Description: An autosomal dominant neuromuscular disorder which usually presents in early adulthood, characterized by progressive muscular atrophy (most frequently involving the hands, forearms, and face), myotonia, frontal baldness, lenticular opacities, and testicular atrophy. Cardiac conduction abnormalities, diaphragmatic weakness, and mild mental retardation may also occur. Congenital myotonic dystrophy is a severe form of this disorder, characterized by neonatal MUSCLE HYPOTONIA, feeding difficulties, respiratory muscle weakness, and an increased incidence of MENTAL RETARDATION. (From Adams et al., Principles of Neurology, 6th ed, pp1423-5; Joynt, Clinical Neurology, 1997, Ch16, pp16-7)

Also Known As: Dystrophia Myotonica; Myotonia Atrophica; Myotonia Dystrophica; Steinert Disease; Congenital Myotonic Dystrophy Show All >>

Networked: 1654 relevant articles (27 outcomes, 131 trials/studies) for this Disease

Key Drugs and Agents for Myotonic Dystrophy

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Glucose (Dextrose) : 3 outcomes 7 studies in 40 results : FDA 175 Generic
  2. Insulin (Novolin) : 2 outcomes 12 studies in 60 results : FDA 2
  3. Phenytoin (Dilantin) : 2 outcomes 1 study in 5 results : FDA 9 Generic
  4. Selegiline (E250) : 2 outcomes 1 study in 3 results : FDA 17 Generic
  5. DNA (Deoxyribonucleic Acid) : 1 outcome 6 studies in 109 results : IBA
  6. modafinil (armodafinil) : 1 outcome 3 studies in 9 results : FDA 10
  7. Creatine : 1 outcome 3 studies in 7 results : IBA
  8. Hormones : 1 outcome 2 studies in 14 results : IBA
  9. Cholesterol : 1 outcome 1 study in 3 results : IBA
  10. Carbamazepine (Tegretol) : 1 outcome 1 study in 2 results : FDA 24 Generic
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Diseases Related to Myotonic Dystrophy

  1. Myotonia
  2. Insulin Resistance
  3. Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy)
  4. Muscular Dystrophies (Muscular Dystrophy)
  5. Muscle Weakness
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Key Therapies for Myotonic Dystrophy

Efficacy Chart >>
  1. Resistance Training : 3 outcomes 4 studies in 8 results
  2. Epidural Anesthesia : 1 outcome in 9 results
  3. Defibrillators (Defibrillator) : 1 outcome in 3 results
  4. General Anesthesia : 1 study in 13 results
  5. Therapeutics : 1 study in 4 results
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