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Myeloproliferative Disorders (Myeloproliferative Disorder) Summary

Description: Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.

Also Known As: Myeloproliferative Disorder; Disorder, Myeloproliferative; Disorders, Myeloproliferative

Networked: 1177 relevant articles (44 outcomes, 88 trials/studies) for this Disease

Key Drugs and Agents for Myeloproliferative Disorders

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Drugs and Important Biological Agents (IBA) related to treatments:
  1. Interferon-alpha (Interferon Alfa) : 6 outcomes 1 study in 34 results : FDA 2
  2. anagrelide (Agrylin) : 3 outcomes 6 studies in 30 results : FDA 9 Generic
  3. imatinib (Gleevec) : 3 outcomes 3 studies in 37 results : FDA 3
  4. Aspirin (Acetylsalicylic Acid) : 3 outcomes 2 studies in 12 results : FDA 80 Generic
  5. Hydroxyurea (Hydrea) : 3 outcomes 1 study in 69 results : FDA 6 Generic
  6. Protein-Tyrosine Kinases (Tyrosine Kinase) : 2 outcomes 6 studies in 84 results : IBA
  7. Messenger RNA (mRNA) : 2 outcomes 2 studies in 20 results : IBA
  8. ranimustine : 1 outcome 4 studies in 5 results : IBA
  9. Phosphotransferases (Kinase) : 1 outcome 3 studies in 64 results : IBA
  10. Janus Kinase 2 : 1 outcome 2 studies in 53 results : IBA
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Diseases Related to Myeloproliferative Disorders

  1. Thrombocytosis (Thrombocythemia)
  2. BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
  3. Essential Thrombocythemia
  4. Lymphoma (Lymphomas)
  5. Polycythemia Vera
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Key Therapies for Myeloproliferative Disorders

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 4 outcomes 3 studies in 38 results
  2. Splenectomy : 3 outcomes 1 study in 29 results
  3. Bone Marrow Transplantation (Transplantation, Bone Marrow) : 2 outcomes 3 studies in 10 results
  4. Hematopoietic Stem Cell Transplantation : 1 outcome 1 study in 5 results
  5. Radiotherapy : 1 outcome 1 study in 4 results
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