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Myasthenia Gravis Summary

Description: A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION, impairing the transmission of impulses to skeletal muscles. Clinical manifestations may include diplopia, ptosis, and weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles. THYMOMA is commonly associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p1459)

Also Known As: Myasthenia Gravis, Generalized; Myasthenia Gravis, Ocular; Generalized Myasthenia Gravis; Ocular Myasthenia Gravis

Networked: 5508 relevant articles (318 outcomes, 420 trials/studies) for this Disease

Key Drugs and Agents for Myasthenia Gravis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Intravenous Immunoglobulins (IVIG) : 26 outcomes 22 studies in 93 results : FDA 1
  2. Acetylcholine (Acetylcholine Chloride) : 20 outcomes 53 studies in 1032 results : FDA 2
  3. Immunoglobulins (Immunoglobulin) : 14 outcomes 15 studies in 145 results : IBA
  4. Cholinesterase Inhibitors (Anticholinesterases) : 14 outcomes 3 studies in 80 results : IBA
  5. Antibodies : 13 outcomes 26 studies in 878 results : IBA
  6. Tacrolimus (Prograf) : 11 outcomes 7 studies in 52 results : FDA 7 Generic
  7. Prednisolone (Predate) : 11 outcomes 5 studies in 47 results : FDA 55 Generic
  8. Prednisone (Sone) : 10 outcomes 16 studies in 87 results : FDA 119 Generic
  9. Adrenal Cortex Hormones (Corticosteroids) : 10 outcomes 3 studies in 74 results : IBA
  10. rituximab (Mabthera) : 10 outcomes 2 studies in 44 results : FDA 3
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Diseases Related to Myasthenia Gravis

  1. Thymoma (Thymic Carcinoma)
  2. Multiple Sclerosis
  3. Polyneuropathies (Polyneuropathy)
  4. Dermatomyositis (Dermatopolymyositis)
  5. Systemic Lupus Erythematosus (Libman-Sacks Disease)
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Key Therapies for Myasthenia Gravis

Efficacy Chart >>
  1. Thymectomy : 120 outcomes 100 studies in 1199 results
  2. Plasma Exchange : 23 outcomes 24 studies in 128 results
  3. Plasmapheresis : 19 outcomes 10 studies in 146 results
  4. Aftercare (After-Treatment) : 5 outcomes 2 studies in 18 results
  5. Drug Therapy (Chemotherapy) : 5 outcomes in 36 results
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