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Methotrexate (Mexate) Summary

Description: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

Also Known As: Mexate; Methotrexate Hydrate; Methotrexate, (D)-Isomer; Methotrexate, (DL)-Isomer; Methotrexate, Dicesium Salt; Methotrexate, Disodium Salt; Methotrexate, Sodium Salt; Dicesium Salt Methotrexate; Disodium Salt Methotrexate; Hydrate, Methotrexate; Sodium Salt Methotrexate; Amethopterin; L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-

Networked: 15850 relevant articles (1641 outcomes, 2464 trials/studies) for this Drug

Key Diseases for which Methotrexate is Relevant

  1. Rheumatoid Arthritis : 388 outcomes 563 studies in 2814 results
  2. Psoriasis (Pustulosis Palmaris et Plantaris) : 104 outcomes 91 studies in 939 results
  3. Neoplasms (Cancer) : 102 outcomes 256 studies in 1785 results
  4. Lymphoma (Lymphomas) : 80 outcomes 75 studies in 633 results
  5. Crohn Disease (Crohn's Disease) : 67 outcomes 36 studies in 203 results
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Drugs Related to Methotrexate

  1. Cyclophosphamide (Cytoxan)
  2. Doxorubicin (Adriamycin)
  3. Fluorouracil (Carac)
  4. Cyclosporine (Ciclosporin)
  5. Cisplatin (Platino)
  6. Vincristine (Oncovin)
  7. infliximab (Remicade)
  8. TNFR-Fc fusion protein (etanercept)
  9. Vinblastine (Vinblastine Sulfate)
  10. Azathioprine (Imuran)
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Therapies Related to Methotrexate

  1. Drug Therapy (Chemotherapy)
  2. Combination Drug Therapy (Combination Chemotherapy)
  3. Radiotherapy
  4. Remission Induction
  5. Adjuvant Chemotherapy
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