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Progressive Multifocal Leukoencephalopathy Summary

Description: An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)

Also Known As: Leukoencephalopathy, Progressive Multifocal; JC Polyomavirus Encephalopathy; Encephalopathies, JC Polyomavirus; Encephalopathy, JC Polyomavirus; JC Polyomavirus Encephalitis Show All >>

Networked: 864 relevant articles (54 outcomes, 54 trials/studies) for this Disease

Key Drugs and Agents for Progressive Multifocal Leukoencephalopathy

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. natalizumab (Tysabri) : 20 outcomes 19 studies in 282 results : FDA 2
  2. Mefloquine (Lariam) : 6 outcomes 2 studies in 18 results : FDA 6 Generic
  3. cidofovir (Vistide) : 3 outcomes 3 studies in 35 results : FDA 1
  4. Antibodies : 2 outcomes 2 studies in 22 results : IBA
  5. N-acetyltalosaminuronic acid (NAT) : 2 outcomes 1 study in 4 results : IBA
  6. nitazoxanide (NTZ) : 2 outcomes in 11 results : FDA 3
  7. Risperidone (Risperdal Consta) : 2 outcomes in 4 results : FDA 35 Generic
  8. DNA (Deoxyribonucleic Acid) : 1 outcome 3 studies in 85 results : IBA
  9. rituximab (Mabthera) : 1 outcome 2 studies in 56 results : FDA 3
  10. Cytarabine (Cytosar-U) : 1 outcome 2 studies in 18 results : FDA 13 Generic
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Diseases Related to Progressive Multifocal Leukoencephalopathy

  1. Acquired Immunodeficiency Syndrome (AIDS)
  2. Multiple Sclerosis
  3. Crohn Disease (Crohn's Disease)
  4. Infection
  5. Opportunistic Infections (Opportunistic Infection)
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Key Therapies for Progressive Multifocal Leukoencephalopathy

Efficacy Chart >>
  1. Highly Active Antiretroviral Therapy (HAART) : 7 outcomes 4 studies in 62 results
  2. Therapeutics : 1 outcome 1 study in 3 results
  3. Aftercare (After-Treatment) : 1 outcome in 14 results
  4. Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) : 1 outcome in 2 results
  5. Radiotherapy : 1 outcome in 1 result
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