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Klinefelter Syndrome (Klinefelter's Syndrome) Summary

Description: A form of male HYPOGONADISM, characterized by the presence of an extra X CHROMOSOME, small TESTES, seminiferous tubule dysgenesis, elevated levels of GONADOTROPINS, low serum TESTOSTERONE, underdeveloped secondary sex characteristics, and male infertility (INFERTILITY, MALE). Patients tend to have long legs and a slim, tall stature. GYNECOMASTIA is present in many of the patients. The classic form has the karyotype 47,XXY. Several karyotype variants include 48,XXYY; 48,XXXY; 49,XXXXY, and mosaic patterns ( 46,XY/47,XXY; 47,XXY/48,XXXY, etc.).

Also Known As: Klinefelter's Syndrome; Syndrome, Klinefelter's; 48,XXYY Syndrome; 49,XXXXY Syndrome; Klinefelter Syndrome, Variants Show All >>

Networked: 849 relevant articles (11 outcomes, 73 trials/studies) for this Disease

Key Drugs and Agents for Klinefelter Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Testosterone (Sustanon) : 7 outcomes 10 studies in 154 results : FDA 13
  2. XXY syndrome : 2 outcomes 17 studies in 295 results : IBA
  3. Hormones : 1 outcome 3 studies in 49 results : IBA
  4. Estradiol (Estrace) : 1 outcome 2 studies in 14 results : FDA 44 Generic
  5. Aromatase Inhibitors : 1 outcome in 1 result : IBA
  6. Testolactone (Teslac) : 1 outcome in 1 result : FDA 2
  7. Methylphenidate (Ritalin) : 1 outcome in 1 result : FDA 25 Generic
  8. Lithium : 1 outcome in 1 result : IBA
  9. anastrozole (Arimidex) : 1 outcome in 1 result : FDA 15 Generic
  10. Chromatin : 5 studies in 41 results : IBA
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Diseases Related to Klinefelter Syndrome

  1. Bipolar Disorder (Mania)
  2. Tremor (Tremors)
  3. Essential Tremor (Essential Tremors)
  4. Turner Syndrome (Turner's Syndrome)
  5. Hypogonadism (Hypergonadotropic Hypogonadism)
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Key Therapies for Klinefelter Syndrome

Efficacy Chart >>
  1. Deep Brain Stimulation : 1 outcome in 1 result
  2. Drug Therapy (Chemotherapy) : 2 studies in 7 results
  3. Ligation : 1 study in 2 results
  4. Renal Dialysis (Hemodialysis) : 1 study in 1 result
  5. Aftercare (After-Treatment) : 5 results
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