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Kernicterus Summary

Description: A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)

Also Known As: Encephalopathy, Bilirubin; Encephalopathy, Hyperbilirubinemic; Bilirubin Encephalopathies; Encephalopathies, Bilirubin; Encephalopathies, Hyperbilirubinemic Show All >>

Networked: 450 relevant articles (12 outcomes, 46 trials/studies) for this Disease

Key Drugs and Agents for Kernicterus

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Bilirubin : 7 outcomes 34 studies in 304 results : IBA
  2. Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase) : 1 outcome in 23 results : IBA
  3. bilirubin glucuronoside glucuronosyltransferase : 1 outcome in 3 results : IBA
  4. Phenobarbital (Luminal) : 1 outcome in 2 results : FDA 1
  5. Metalloporphyrins : 1 outcome in 1 result : IBA
  6. bucolome : 1 outcome in 1 result : IBA
  7. Protons (Proton) : 2 studies in 3 results : IBA
  8. Carrier Proteins (Binding Protein) : 2 studies in 3 results : IBA
  9. Sulfisoxazole (Sulfafurazole) : 1 study in 5 results : FDA 25
  10. Sulfadimethoxine : 1 study in 5 results : IBA
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Diseases Related to Kernicterus

  1. Hyperbilirubinemia
  2. Jaundice
  3. Glucosephosphate Dehydrogenase Deficiency
  4. Kernicterus
  5. Neonatal Jaundice
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Key Therapies for Kernicterus

Efficacy Chart >>
  1. Phototherapy (Light Therapy) : 4 outcomes 5 studies in 39 results
  2. Liver Transplantation : 1 outcome in 6 results
  3. Patient Isolation : 1 outcome in 1 result
  4. Intrauterine Blood Transfusion : 1 study in 1 result
  5. Drug Therapy (Chemotherapy) : 6 results
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