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Aprotinin (Trasylol) Summary

Description: A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

Also Known As: Trasylol; Antilysin; Arzneimittelwerk Dresden Brand of Aprotinin; Bayer Brand of Aprotinin; Bovine Pancreatic Trypsin Inhibitor Show All >>

Networked: 1387 relevant articles (149 outcomes, 209 trials/studies) for this Drug

Key Diseases for which Aprotinin is Relevant

  1. Hemorrhage : 43 outcomes 62 studies in 335 results
  2. Postoperative Hemorrhage : 18 outcomes 6 studies in 94 results
  3. Reperfusion Injury : 10 outcomes 6 studies in 37 results
  4. Pancreatitis : 8 outcomes 19 studies in 142 results
  5. Stroke (Strokes) : 5 outcomes 6 studies in 31 results
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Drugs Related to Aprotinin

  1. Tranexamic Acid (AMCA)
  2. Aprotinin (Trasylol)
  3. Serine Proteases (Serine Protease)
  4. 6-Aminocaproic Acid (6 Aminocaproic Acid)
  5. Kallikreins (Kallikrein)
  6. Protease Inhibitors (Protease Inhibitor)
  7. Lysine (L-Lysine)
  8. Fibrin Tissue Adhesive (Fibrin Sealant)
  9. Fibrinolysin
  10. Peptide Hydrolases (Proteases)
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Therapies Related to Aprotinin

  1. Cardiopulmonary Bypass (Heart-Lung Bypass)
  2. Transplants (Transplant)
  3. Blood Transfusion (Blood Transfusions)
  4. Coronary Artery Bypass (Coronary Artery Bypass Surgery)
  5. Lung Transplantation
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