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Kainic Acid (Kainate) Summary

Description: (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.

Also Known As: Kainate; Acid, Digenic; Acid, Kainic; Digenic Acid; 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S-(2alpha,3beta,4beta))-

Networked: 3020 relevant articles (110 outcomes, 443 trials/studies) for this Bio-Agent

Key Diseases for which Kainic Acid is Relevant

  1. Seizures (Seizure) : 77 outcomes 226 studies in 1764 results
  2. Status Epilepticus (Complex Partial Status Epilepticus) : 10 outcomes 64 studies in 460 results
  3. Epilepsy (Aura) : 8 outcomes 62 studies in 332 results
  4. Temporal Lobe Epilepsy : 4 outcomes 41 studies in 227 results
  5. Ischemia : 4 outcomes 12 studies in 85 results
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Drugs Related to Kainic Acid

  1. alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
  2. N-Methylaspartate (NMDA)
  3. Pilocarpine (Ocusert)
  4. Pentylenetetrazole (Metrazol)
  5. Picrotoxin
  6. topiramate (Topamax)
  7. Glutamic Acid (Glutamate)
  8. 4-Aminopyridine (4 Aminopyridine)
  9. Bicuculline
  10. AMPA Receptors (AMPA Receptor)
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Therapies Related to Kainic Acid

  1. Injections
  2. Aftercare (After-Treatment)
  3. Intraventricular Infusions
  4. Intramuscular Injections
  5. Electroacupuncture
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