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Huntington Disease (Huntington's Disease) Summary

3153 relevant articles (97 outcomes, 322 trials/studies) found for this Disease

Description: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

Also Known As: Huntington's Disease; Huntington's Chorea; Progressive Chorea, Chronic Hereditary (Huntington); Chorea, Huntington; Chorea, Huntington's Show All >>

Key Drugs and Agents for Huntington Disease

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. polyglutamine : 5 outcomes 10 studies in 491 results : IBA
  2. Minocycline (Cyclops) : 5 outcomes 4 studies in 24 results : FDA 21 Generic
  3. gamma-Aminobutyric Acid (GABA) : 4 outcomes 10 studies in 96 results : IBA
  4. Quinolinic Acid : 4 outcomes 8 studies in 132 results : IBA
  5. Genetic Markers (Genetic Marker) : 3 outcomes 6 studies in 74 results : IBA
  6. Brain-Derived Neurotrophic Factor (BDNF) : 3 outcomes 2 studies in 51 results : IBA
  7. ethyl eicosapentaenoic acid : 3 outcomes 2 studies in 5 results : IBA
  8. Trehalose : 3 outcomes in 3 results : IBA
  9. DNA (Deoxyribonucleic Acid) : 2 outcomes 13 studies in 159 results : IBA
  10. Proteins (Proteins, Gene) : 2 outcomes 9 studies in 156 results : IBA
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Diseases Related to Huntington Disease

  1. Parkinson Disease (Parkinson's Disease)
  2. Dyskinesias (Dyskinesia)
  3. Chorea (Rheumatic Chorea)
  4. Stroke (Strokes)
  5. Neurodegenerative Diseases (Neurodegenerative Disease)
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Key Therapies for Huntington Disease

Efficacy Chart >>
  1. Transplantation (Transplant Recipients) : 5 outcomes 15 studies in 79 results
  2. Aftercare (After-Treatment) : 3 outcomes in 7 results
  3. Transplants (Transplant) : 2 outcomes 17 studies in 88 results
  4. Homologous Transplantation (Allograft) : 1 outcome 1 study in 8 results
  5. Drug Therapy (Chemotherapy) : 1 outcome in 9 results
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