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Huntington Disease (Huntington's Disease) Summary

Description: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

Also Known As: Huntington's Disease; Huntington's Chorea; Progressive Chorea, Chronic Hereditary (Huntington); Chorea, Huntington; Chorea, Huntington's Show All >>

Networked: 5093 relevant articles (171 outcomes, 507 trials/studies) for this Disease

Key Drugs and Agents for Huntington Disease

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. polyglutamine : 10 outcomes 20 studies in 1074 results : IBA
  2. Quinolinic Acid : 7 outcomes 17 studies in 164 results : IBA
  3. Minocycline (Cyclops) : 7 outcomes 8 studies in 38 results : FDA 25 Generic
  4. 3-nitropropionic acid : 4 outcomes 38 studies in 173 results : IBA
  5. Proteins (Proteins, Gene) : 4 outcomes 17 studies in 319 results : IBA
  6. N-Methylaspartate (NMDA) : 4 outcomes 9 studies in 87 results : IBA
  7. Genetic Markers (Genetic Marker) : 4 outcomes 7 studies in 78 results : IBA
  8. Brain-Derived Neurotrophic Factor (BDNF) : 4 outcomes 4 studies in 107 results : IBA
  9. ethyl eicosapentaenoic acid : 4 outcomes 3 studies in 7 results : IBA
  10. Melatonin : 4 outcomes 2 studies in 16 results : IBA
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Diseases Related to Huntington Disease

  1. Parkinson Disease (Parkinson's Disease)
  2. Alzheimer Disease (Alzheimer's Disease)
  3. Neurodegenerative Diseases (Neurodegenerative Disease)
  4. Stroke (Strokes)
  5. Chorea (Rheumatic Chorea)
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Key Therapies for Huntington Disease

Efficacy Chart >>
  1. Transplantation (Transplant Recipients) : 9 outcomes 19 studies in 119 results
  2. Transplants (Transplant) : 5 outcomes 19 studies in 116 results
  3. Aftercare (After-Treatment) : 3 outcomes in 8 results
  4. Tissue Therapy (Cell Therapy) : 2 outcomes 2 studies in 21 results
  5. Therapeutics : 1 outcome 5 studies in 47 results
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