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von Hippel-Lindau Disease (von Hippel Lindau Disease) Summary

Description: An autosomal dominant disorder caused by mutations in a tumor suppressor gene. This syndrome is characterized by abnormal growth of small blood vessels leading to a host of neoplasms. They include HEMANGIOBLASTOMA in the RETINA; CEREBELLUM; and SPINAL CORD; PHEOCHROMOCYTOMA; pancreatic tumors; and renal cell carcinoma (see CARCINOMA, RENAL CELL). Common clinical signs include HYPERTENSION and neurological dysfunctions.

Also Known As: von Hippel Lindau Disease; von Hippel-Lindau Syndrome; Syndrome, von Hippel-Lindau; Cerebelloretinal Angiomatosis, Familial; Familial Cerebello-Retinal Angiomatosis Show All >>

Networked: 409 relevant articles (3 outcomes, 27 trials/studies) for this Disease

Key Drugs and Agents for von Hippel-Lindau Disease

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Retinaldehyde (Retinal) : 1 outcome 6 studies in 120 results : IBA
  2. bevacizumab : 1 outcome in 5 results : FDA 2
  3. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor) : 3 studies in 13 results : IBA
  4. Succinate Dehydrogenase (Fumarate Reductase) : 2 studies in 27 results : IBA
  5. DNA (Deoxyribonucleic Acid) : 2 studies in 19 results : IBA
  6. sunitinib (Sutent) : 2 studies in 6 results : FDA 2
  7. Messenger RNA (mRNA) : 2 studies in 3 results : IBA
  8. Islet cell tumor syndrome : 1 study in 17 results : IBA
  9. Gadolinium DTPA (Magnevist) : 1 study in 3 results : FDA 2
  10. Turcot syndrome : 1 study in 2 results : IBA
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Diseases Related to von Hippel-Lindau Disease

  1. Renal Cell Carcinoma (Grawitz Tumor)
  2. Hemangioblastoma
  3. Neurofibromatoses (Neurofibromatosis)
  4. Neurocutaneous Syndromes (Phakomatoses)
  5. Sturge-Weber Syndrome (Sturge-Kalischer-Weber Syndrome)
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Key Therapies for von Hippel-Lindau Disease

Efficacy Chart >>
  1. Nephrectomy : 1 outcome 1 study in 20 results
  2. Light Coagulation : 1 outcome in 9 results
  3. Lasers (Laser) : 1 outcome in 6 results
  4. Renal Dialysis (Hemodialysis) : 1 outcome in 6 results
  5. Transplantation (Transplant Recipients) : 1 outcome in 2 results
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